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Forst T, Weber MM, Mitry M, et al. Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy. J Diabetes Sci Technol. 2014;8(2):356-361doi: 10.1177/1932296814524092.
Forst, T., Weber, M. M., Mitry, M., Müller, L., Forst, S., Tanis, M., Pfützner, A., & Michelson, G. (2014). Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy. Journal of diabetes science and technology, 8(2), 356-361. https://doi.org/10.1177/1932296814524092
Forst, Thomas, et al. "Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy." Journal of diabetes science and technology vol. 8,2 (2014): 356-361. doi: https://doi.org/10.1177/1932296814524092
Forst T, Weber MM, Mitry M, Müller L, Forst S, Tanis M, Pfützner A, Michelson G. Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy. J Diabetes Sci Technol. 2014 Mar;8(2):356-361. doi: 10.1177/1932296814524092. Epub 2014 Feb 21. PMID: 24876588; PMCID: PMC4455410.
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J Diabetes Sci Technol. 2014 Mar;8(2):356-361. doi: 10.1177/1932296814524092. Epub 2014 Feb 21.

Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy.

Journal of diabetes science and technology

Thomas Forst, Matthias M Weber, Michael Mitry, Lena Müller, Senait Forst, Mukkadar Tanis, Andreas Pfützner, Georg Michelson

Affiliations

  1. Profil Mainz, Mainz, Germany Johannes Gutenberg University, 1st Medical Department, Endocrinology, Mainz, Germany [email protected].
  2. Johannes Gutenberg University, 1st Medical Department, Endocrinology, Mainz, Germany.
  3. Institute for Clinical Research and Development, Mainz, Germany.
  4. Profil Mainz, Mainz, Germany.
  5. Friedrich-Alexander-University, Interdisciplinary Center for Ophthalmic Preventive Medicine and Imaging, Erlangen-Nuernberg, Germany.

PMID: 24876588 PMCID: PMC4455410 DOI: 10.1177/1932296814524092

Abstract

In patients with diabetes mellitus (DM), early retinal microvascular alterations can be observed even before the clinical diagnosis of diabetic retinopathy. This study aimed to investigate morphological and functional changes in retinal microvascular blood flow in type 1 diabetic patients with and without peripheral neuropathy (PNP) as compared to nondiabetic controls. Retinal microvascular blood flow (RBF) was assessed using scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter, Heidelberg Engineering, Germany) before and after stimulation with flicker light. PNP was assessed using the neuropathy disability score (NDS) and by the evaluation of the vibration perception threshold (VPT). A total of 41 subjects were recruited for study participation and were stratified to 3 different groups according to their metabolic and neurological status: 14 nondiabetic subjects without PNP, 14 diabetic patients without PNP, and 13 diabetic patients with PNP. All subjects were free from diabetic retinopathy as assessed by fundoscopy. In diabetic patients with PNP, baseline and stimulated RBF was higher compared with diabetic patients without PNP and the nondiabetic control group. No difference with regard to RBF could be observed between the nondiabetic control subjects and patients with type 1 DM without PNP. No difference in the arterial WLR could be observed between the 3 groups. A linear correlation was found for VPT and RBF (r = .38, P < .001) and for NDS and RBF (r = .44, P < .0001). In our study population of patients with type 1 diabetes, PNP was associated with functional but not morphological changes in RBF.

© 2014 Diabetes Technology Society.

Keywords: diabetic polyneuropathy; retinal blood flow; type 1 diabetes mellitus; wall to lumen ratio

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