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Villegas VM, Gold AS, Berrocal AM, et al. Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. Clin Ophthalmol. 2014;8:973-6doi: 10.2147/OPTH.S62816.
Villegas, V. M., Gold, A. S., Berrocal, A. M., & Murray, T. G. (2014). Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. Clinical ophthalmology (Auckland, N.Z.), 8973-6. https://doi.org/10.2147/OPTH.S62816
Villegas, Victor M, et al. "Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation." Clinical ophthalmology (Auckland, N.Z.) vol. 8 (2014): 973-6. doi: https://doi.org/10.2147/OPTH.S62816
Villegas VM, Gold AS, Berrocal AM, Murray TG. Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. Clin Ophthalmol. 2014 May 16;8:973-6. doi: 10.2147/OPTH.S62816. eCollection 2014. PMID: 24876764; PMCID: PMC4037307.
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Clin Ophthalmol. 2014 May 16;8:973-6. doi: 10.2147/OPTH.S62816. eCollection 2014.

Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation.

Clinical ophthalmology (Auckland, N.Z.)

Victor M Villegas, Aaron S Gold, Audina M Berrocal, Timothy G Murray

Affiliations

  1. Ocular Oncology and Retina, Miami, FL, USA.
  2. Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.

PMID: 24876764 PMCID: PMC4037307 DOI: 10.2147/OPTH.S62816

Abstract

PURPOSE: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats' disease presenting with exudative retinal detachment.

METHODS: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats' disease. Mean patient age was 62 months (range 9-160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection.

RESULTS: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications.

CONCLUSION: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats' disease presenting with exudative retinal detachment.

Keywords: Coats’ disease; anti-VEGF; bevacizumab; laser ablation; retina

References

  1. Graefes Arch Clin Exp Ophthalmol. 2011 Jul;249(7):1099-101 - PubMed
  2. Retina. 2010 Apr;30(4):617-22 - PubMed
  3. Ophthalmic Surg Lasers Imaging. 2010 Nov-Dec;41(6):582-92 - PubMed
  4. Br J Ophthalmol. 2012 Mar;96(3):356-9 - PubMed
  5. Acta Ophthalmol. 2014 May;92(3):e225-8 - PubMed
  6. Am J Ophthalmol. 2001 May;131(5):561-71 - PubMed
  7. Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1519-21 - PubMed
  8. Retina. 2006 Apr;26(4):422-4 - PubMed
  9. Br J Ophthalmol. 2013 Mar;97(3):272-7 - PubMed
  10. Graefes Arch Clin Exp Ophthalmol. 2007 Sep;245(9):1387-8 - PubMed
  11. Am J Ophthalmol. 1956 Jul;42(1):1-8 - PubMed
  12. Retina. 2008 Mar;28(3 Suppl):S38-41 - PubMed
  13. Indian J Ophthalmol. 2010 Jan-Feb;58(1):80-2 - PubMed
  14. Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):57-62 - PubMed

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