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Masoumi K, Forouzan A, Haddadzadeh Shoushtari M, et al. The efficacy of nebulized furosemide and salbutamol compared with salbutamol alone in reactive airway disease: a double blind randomized, clinical trial. Emerg Med Int. 2014;2014:638102doi: 10.1155/2014/638102.
Masoumi, K., Forouzan, A., Haddadzadeh Shoushtari, M., Porozan, S., Feli, M., Fallah Bagher Sheidaee, M., & Asgari Darian, A. (2014). The efficacy of nebulized furosemide and salbutamol compared with salbutamol alone in reactive airway disease: a double blind randomized, clinical trial. Emergency medicine international, 2014638102. https://doi.org/10.1155/2014/638102
Masoumi, Kambiz, et al. "The efficacy of nebulized furosemide and salbutamol compared with salbutamol alone in reactive airway disease: a double blind randomized, clinical trial." Emergency medicine international vol. 2014 (2014): 638102. doi: https://doi.org/10.1155/2014/638102
Masoumi K, Forouzan A, Haddadzadeh Shoushtari M, Porozan S, Feli M, Fallah Bagher Sheidaee M, Asgari Darian A. The efficacy of nebulized furosemide and salbutamol compared with salbutamol alone in reactive airway disease: a double blind randomized, clinical trial. Emerg Med Int. 2014;2014:638102. doi: 10.1155/2014/638102. Epub 2014 Apr 27. PMID: 24876968; PMCID: PMC4020390.
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Emerg Med Int. 2014;2014:638102. doi: 10.1155/2014/638102. Epub 2014 Apr 27.

The efficacy of nebulized furosemide and salbutamol compared with salbutamol alone in reactive airway disease: a double blind randomized, clinical trial.

Emergency medicine international

Kambiz Masoumi, Arash Forouzan, Maryam Haddadzadeh Shoushtari, Samaneh Porozan, Maryam Feli, Mehdi Fallah Bagher Sheidaee, Ali Asgari Darian

Affiliations

  1. Department of Emergency Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6193673166, Iran.
  2. Department of Internal Medicine, Division of Pulmonology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6193673166, Iran.

PMID: 24876968 PMCID: PMC4020390 DOI: 10.1155/2014/638102

Abstract

We undertook this randomized clinical trial to investigate whether adding furosemide to salbutamol could improve the peak expiratory flow rate (PEFR) and clinical signs of reactive airway disease (RAD) patients. Eligible 18- to 55-year-old patients were randomly divided into intervention and control groups. Patients received 5 mg of nebulized salbutamol and 40 mg of nebulized furosemide in the intervention group and 5 mg of nebulized salbutamol alone in the control group. Patients in both groups received 100 mg of methylprednisolone intravenously stat. Severity of the RAD was estimated before and 45 minutes after treatment in both groups. PEFR was estimated before treatment and at 15, 30, and 45 minutes later. Ninety patients were enrolled, 45 in each group. There were no significant differences between two groups regarding gender, mean age, and normalized PEFR. The baseline mean PEFR was not significantly different between groups (P = 0.58). A repeated measure analysis of variance revealed that the differences between the two treatments was significant (P = 0.0001) and the behavior of two treatments was not similar across the time (P = 0.001). Comparison of clinical severity of acute RAD revealed no significant differences between groups at the end of the trial (0.06). This study showed that adding nebulized furosemide to salbutamol in RAD patients improved PEFR.

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