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Kitahara T, Uemura M, Haraguchi N, et al. Successful treatment of rectal cancer with perineal invasion: Three case reports. Mol Clin Oncol. 2014;2(4):497-500doi: 10.3892/mco.2014.282.
Kitahara, T., Uemura, M., Haraguchi, N., Nishimura, J., Shingai, T., Hata, T., Takemasa, I., Mizushima, T., Doki, Y., Mori, M., & Yamamoto, H. (2014). Successful treatment of rectal cancer with perineal invasion: Three case reports. Molecular and clinical oncology, 2(4), 497-500. https://doi.org/10.3892/mco.2014.282
Kitahara, Tomohiro, et al. "Successful treatment of rectal cancer with perineal invasion: Three case reports." Molecular and clinical oncology vol. 2,4 (2014): 497-500. doi: https://doi.org/10.3892/mco.2014.282
Kitahara T, Uemura M, Haraguchi N, Nishimura J, Shingai T, Hata T, Takemasa I, Mizushima T, Doki Y, Mori M, Yamamoto H. Successful treatment of rectal cancer with perineal invasion: Three case reports. Mol Clin Oncol. 2014 Jul;2(4):497-500. doi: 10.3892/mco.2014.282. Epub 2014 Apr 17. PMID: 24940483; PMCID: PMC4051571.
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Mol Clin Oncol. 2014 Jul;2(4):497-500. doi: 10.3892/mco.2014.282. Epub 2014 Apr 17.

Successful treatment of rectal cancer with perineal invasion: Three case reports.

Molecular and clinical oncology

Tomohiro Kitahara, Mamoru Uemura, Naotsugu Haraguchi, Junichi Nishimura, Tatsushi Shingai, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
  2. Department of Gastroenterological Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Osaka 540-0006, Japan.
  3. Department of Surgery, Saiseikai Senri Hospital, Suita, Osaka 565-0862, Japan.

PMID: 24940483 PMCID: PMC4051571 DOI: 10.3892/mco.2014.282

Abstract

Rectal cancer occasionally invades adjacent organs. However, rectal cancer with perineal invasion is uncommon and difficult to treat. Locally advanced colorectal cancer may be clinically treated with neoadjuvant therapy, followed by en bloc resection. Skin invasion may lead to tumor dissemination via cutaneous blood flow and lymphatic routes. There is currently no firm evidence regarding the treatment of these significantly advanced rectal cancers. In this study, we report 3 cases of rectal cancer with perineal invasion, successfully managed by multimodality treatment. Case 1 is a 52-year-old man with rectal cancer that had invaded the perineum; case 2 is a 38-year-old man with rectal cancer infiltrating the perineal skin and liver metastasis; and case 3 is a 50-year-old woman with rectal cancer and perineal invasion. All the cases were treated with radical excision. No severe complications were observed in the perioperative period. Case 2, in particular, was confirmed to remain alive 5 years after the surgery. Our experience suggests that multimodality treatment, including extended radical surgery, may be a feasible approach to the treatment of rectal cancer with perineal skin invasion.

Keywords: extended radical surgery; multimodality treatment; perineal invasion; rectal cancer

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