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Int J Psychiatry Clin Pract. 1998;2(3):225-7. doi: 10.3109/13651509809115361.

Elevated plasma paroxetine concentrations in a patient treated with a combination of paroxetine and pindolol.

International journal of psychiatry in clinical practice

J S Olver, G D Burrows

Affiliations

  1. Department of Psychiatry, Austin.

PMID: 24940982 DOI: 10.3109/13651509809115361

Abstract

Paroxetine and pindolol have been used in combination to augment the antidepressant response of SSEIs. The rationale given involves the prevention of a negative feedback inhibition of serotonergic neurons but few studies have addressed potential pharmacokinetic interactions. This paper reports on elevated plasma paroxetine concentrations in a 37-year-old depressed woman following the introduction of pindolol. This case study supports the possibility of competitive drug-drug interactions in combinations of paroxetine and pindolol.

Keywords: Andole; Depression; Paroxetine; drug interactions; plasma concentrations

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