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Lüftner D, Lorusso V, Duran I, et al. Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study. Springerplus. 2014;3:328doi: 10.1186/2193-1801-3-328.
Lüftner, D., Lorusso, V., Duran, I., Hechmati, G., Garzon-Rodriguez, C., Ashcroft, J., Bahl, A., Ghelani, P., Wei, R., Thomas, E., & Hoefeler, H. (2014). Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study. SpringerPlus, 3328. https://doi.org/10.1186/2193-1801-3-328
Lüftner, Diana, et al. "Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study." SpringerPlus vol. 3 (2014): 328. doi: https://doi.org/10.1186/2193-1801-3-328
Lüftner D, Lorusso V, Duran I, Hechmati G, Garzon-Rodriguez C, Ashcroft J, Bahl A, Ghelani P, Wei R, Thomas E, Hoefeler H. Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study. Springerplus. 2014 Jun 30;3:328. doi: 10.1186/2193-1801-3-328. eCollection 2014. PMID: 25045611; PMCID: PMC4093906.
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Springerplus. 2014 Jun 30;3:328. doi: 10.1186/2193-1801-3-328. eCollection 2014.

Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study.

SpringerPlus

Diana Lüftner, Vito Lorusso, Ignacio Duran, Guy Hechmati, Cristina Garzon-Rodriguez, John Ashcroft, Amit Bahl, Prayashi Ghelani, Rachel Wei, Emma Thomas, Herbert Hoefeler

Affiliations

  1. Charité Universitätsmedizin Berlin, Berlin, Germany.
  2. National Cancer Institute IRCCS Giovanni Paolo II, Bari, Italy ; Oncology Institute ASL, Lecce, Italy.
  3. Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain.
  4. Health Economics, Amgen (Europe) GmbH, Zug, Switzerland.
  5. Instituto Catalán d'Oncología ICO-IDIBELL, Barcelona, Spain.
  6. Pinderfields General Hospital, Wakefield, UK.
  7. University Hospitals Bristol, Bristol, UK.
  8. Biostatistics, Ovatech Solutions, London, UK.
  9. Biostatistics, Amgen Inc, Thousand Oaks, CA USA.
  10. Scientific Publications, Amgen (Europe) GmbH, Zug, Switzerland.
  11. Forschungszentrum Ruhr, Witten, Germany.

PMID: 25045611 PMCID: PMC4093906 DOI: 10.1186/2193-1801-3-328

Abstract

Patients with breast cancer and bone metastases often experience skeletal complications (skeletal-related events [SREs]: pathologic fracture, radiation to bone, surgery to bone or spinal cord compression). Prospective data on the health resource burden of SREs are needed for planning healthcare requirements and estimating the value of new treatments, but limited data are available. This prospective, observational study collected health resource utilization (HRU) data independently attributed to SREs by investigators. Eligible patients had bone metastases secondary to breast cancer, life expectancy ≥6 months, Eastern Cooperative Oncology Group (ECOG) performance status ≤2, and at least one SRE in the 97 days before enrollment. Data, collected retrospectively for 97 days before enrollment and prospectively for 18-21 months, included number and duration of inpatient stays, outpatient visits, emergency room visits and procedures. Altogether, 223 patients were enrolled from Germany, Italy, Spain and the UK. Of the 457 SREs, 118 (25.8%) were associated with inpatient stays. The mean duration of stay was 19.5 (standard deviation [SD] 19.2) days per SRE (based on 117 SREs). Surgery to bone and spinal cord compression were the SREs most likely to require inpatient stays (77.8% and 57.9% of SREs, respectively), while radiation to bone was the least likely (9.7%). Spinal cord compression required the longest inpatient stay per event (34.2 [SD 30.2] days) and radiation to bone the shortest (14.3 [SD 10.2] days). Overall, 342 SREs (74.8%) required an outpatient visit, with radiation to bone the most likely (85.7%), and surgery to bone the least likely (42.6%). Radiation to bone was also associated with the greatest number of outpatient visits per event (6.8 [SD 6.7] visits). All SREs were associated with substantial HRU therefore, preventing SREs in patients with breast cancer may reduce the burden imposed on healthcare systems.

Keywords: Bone metastases; Breast cancer; Europe; Health resource utilization; Skeletal-related events

References

  1. Cancer. 2007 Oct 15;110(8):1860-7 - PubMed
  2. Am J Manag Care. 2008 May;14(5):317-22 - PubMed
  3. Lancet. 2011 Mar 5;377(9768):813-22 - PubMed
  4. Cancer. 2000 Mar 1;88(5):1082-90 - PubMed
  5. Support Care Cancer. 2007 Jul;15(7):869-76 - PubMed
  6. Med Care. 2004 Feb;42(2):164-75 - PubMed
  7. J Clin Oncol. 2011 Mar 20;29(9):1125-32 - PubMed
  8. Eur J Cancer Care (Engl). 2010 Nov;19(6):755-60 - PubMed
  9. Cancer Treat Rev. 2001 Jun;27(3):165-76 - PubMed
  10. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6243s-6249s - PubMed
  11. Support Care Cancer. 2008 Aug;16(8):879-89 - PubMed
  12. J Support Oncol. 2006 Jul-Aug;4(7):341-7 - PubMed
  13. Clin Epidemiol. 2013;5:97-103 - PubMed
  14. Oncology. 2004;67(5-6):390-6 - PubMed
  15. Radiat Oncol. 2012 Aug 03;7:131 - PubMed
  16. Arch Orthop Trauma Surg. 2002 Jun;122(5):251-8 - PubMed
  17. J Manag Care Pharm. 2010 Nov-Dec;16(9):693-702 - PubMed
  18. Cancer. 2007 Jun 1;109(11):2334-42 - PubMed
  19. J Clin Oncol. 2010 Dec 10;28(35):5132-9 - PubMed
  20. J Urol. 2010 Jul;184(1):162-7 - PubMed
  21. BMJ. 2000 Apr 29;320(7243):1197-200 - PubMed
  22. Value Health. 2011 Jun;14(4):499-505 - PubMed
  23. Clin Oncol (R Coll Radiol). 2007 Jun;19(5):273-86 - PubMed
  24. Cancer. 1997 Oct 15;80(8 Suppl):1588-94 - PubMed
  25. J Thorac Oncol. 2011 Mar;6(3):576-82 - PubMed

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