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Slotty PJ, Behrendt FF, Langen KJ, et al. (68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma. J Craniovertebr Junction Spine. 2014;5(1):44-6doi: 10.4103/0974-8237.135224.
Slotty, P. J., Behrendt, F. F., Langen, K. J., & Cornelius, J. F. (2014). (68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma. Journal of craniovertebral junction & spine, 5(1), 44-6. https://doi.org/10.4103/0974-8237.135224
Slotty, Philipp Jörg, et al. "(68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma." Journal of craniovertebral junction & spine vol. 5,1 (2014): 44-6. doi: https://doi.org/10.4103/0974-8237.135224
Slotty PJ, Behrendt FF, Langen KJ, Cornelius JF. (68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma. J Craniovertebr Junction Spine. 2014 Jan;5(1):44-6. doi: 10.4103/0974-8237.135224. PMID: 25013347; PMCID: PMC4085911.
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J Craniovertebr Junction Spine. 2014 Jan;5(1):44-6. doi: 10.4103/0974-8237.135224.

(68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma.

Journal of craniovertebral junction & spine

Philipp Jörg Slotty, Florian Friedrich Behrendt, Karl-Josef Langen, Jan Frederick Cornelius

Affiliations

  1. Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada ; Department of Neurosurgery, Heinrich-Heine University Düsseldorf, Germany.
  2. Department of Nuclear Medicine, University Hospital RWTH Aachen, Germany.
  3. Department of Nuclear Medicine, University Hospital RWTH Aachen, Germany ; Department of Neuroscience and Medicine (INM-4), Jülich Research Centre, Jülich, Germany.
  4. Department of Neurosurgery, Heinrich-Heine University Düsseldorf, Germany.

PMID: 25013347 PMCID: PMC4085911 DOI: 10.4103/0974-8237.135224

Abstract

Imaging with positron emission tomography (PET) and (68)Ga-DOTA peptides is a promising method in intracranial meningiomas. Especially in recurrent meningioma discrimination between scar tissue and recurrent tumor tissue in magnetic resonance imaging (MRI) is often difficult. We report the first case of (68)Ga-DOTATATE-PET/computed tomography (PET/CT) imaging in recurrent spinal meningioma. A 64-year-old Caucasian female patient was referred to our department with the second recurrence of thoracic meningothelial meningioma. In MRI, it remained unclear if the multiple enhancements seen represented scar tissue or vital tumor. We offered (68)Ga-DOTATATE-PET/CT imaging in order to evaluate the best strategy. (68)Ga-DOTATATE-PET/CT imaging revealed strong tracer uptake in parts of the lesions. The pattern did distinctly differ from MRI enhancement. Multiple biopsies were performed in the PET-positive and PET-negative regions. Histological results confirmed the prediction of (68)Ga-DOTATATE-PET with vital tumor in PET-positive regions and scar tissue in PET-negative regions. Differentiating scar tissue from tumor can be challenging in recurrent spinal meningioma with MRI alone. In the presented case, (68)Ga-DOTATATE-PET imaging was able to differentiate noninvasively between tumor and scar.

Keywords: DOTATATE-positron emission tomography/computed tomography; meningioma; metabolic imaging; spinal tumor

References

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