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Weinstein D, Leininger J, Hamby C, et al. Diagnostic and prognostic biomarkers in melanoma. J Clin Aesthet Dermatol. 2014;7(6):13-24
Weinstein, D., Leininger, J., Hamby, C., & Safai, B. (2014). Diagnostic and prognostic biomarkers in melanoma. The Journal of clinical and aesthetic dermatology, 7(6), 13-24.
Weinstein, David, et al. "Diagnostic and prognostic biomarkers in melanoma." The Journal of clinical and aesthetic dermatology vol. 7,6 (2014): 13-24.
Weinstein D, Leininger J, Hamby C, Safai B. Diagnostic and prognostic biomarkers in melanoma. J Clin Aesthet Dermatol. 2014 Jun;7(6):13-24. PMID: 25013535; PMCID: PMC4086529.
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J Clin Aesthet Dermatol. 2014 Jun;7(6):13-24.

Diagnostic and prognostic biomarkers in melanoma.

The Journal of clinical and aesthetic dermatology

David Weinstein, Jennifer Leininger, Carl Hamby, Bijan Safai

Affiliations

  1. Department of Dermatology.
  2. Department of Microbiology and Immunology, New York Medical College, New York and Valhalla, New York.

PMID: 25013535 PMCID: PMC4086529

Abstract

Melanoma is a lethal melanocytic neoplasm. Unfortunately, the histological diagnosis can be difficult at times. Distinguishing ambiguous melanocytic neoplasms that are benign nevi from those that represent true melanoma is important both for treatment and prognosis. Diagnostic biomarkers currently used to assist in the diagnosis of melanoma are usually specific only for melanocytic neoplasms and not necessarily for their ability to metastasize. Traditional prognostic biomarkers include depth of invasion and mitotic count. Newer diagnostic and prognostic biomarkers utilize immunohistochemical staining as well as ribonucleic acid, micro-ribonucleic acid, and deoxyribonucleic acid assays and fluorescence in situ hybridization. Improved diagnostic and prognostic biomarkers are of increasing importance in the treatment of melanoma with the development of newer and more targeted therapies. Herein, the authors review many of the common as well as newer diagnostic and prognostic biomarkers used in melanoma.

References

  1. Mod Pathol. 2004 Oct;17(10):1251-8 - PubMed
  2. Int J Biochem Cell Biol. 2001 Jul;33(7):637-68 - PubMed
  3. Cytokine. 2000 Apr;12(4):374-8 - PubMed
  4. Br J Dermatol. 2011 Apr;164(4):797-806 - PubMed
  5. Am J Pathol. 1986 May;123(2):195-203 - PubMed
  6. J Cutan Pathol. 1998 Apr;25(4):204-9 - PubMed
  7. J Biol Chem. 2005 Apr 8;280(14):14006-16 - PubMed
  8. Cancer Metastasis Rev. 1999;18(3):377-85 - PubMed
  9. Melanoma Res. 2002 Aug;12(4):325-34 - PubMed
  10. Cancer. 2006 Nov 15;107(10):2436-45 - PubMed
  11. Structure. 1999 Feb 15;7(2):169-77 - PubMed
  12. J Clin Oncol. 2010 May 10;28(14):2452-9 - PubMed
  13. Cancer Sci. 2010 Oct;101(10):2087-92 - PubMed
  14. Am J Dermatopathol. 2009 May;31(3):305-8 - PubMed
  15. Br J Dermatol. 2005 Apr;152(4):685-9 - PubMed
  16. Diagn Mol Pathol. 2010 Jun;19(2):78-82 - PubMed
  17. J Plast Reconstr Aesthet Surg. 2008;61(3):265-71 - PubMed
  18. Clin Cancer Res. 2009 Nov 15;15(22):6939-46 - PubMed
  19. Biochim Biophys Acta. 1999 Jul 8;1450(3):191-231 - PubMed
  20. Am J Pathol. 1997 Sep;151(3):745-51 - PubMed
  21. Am J Dermatopathol. 2001 Jun;23(3):185-9 - PubMed
  22. Biochem J. 1927;21(1):89-96 - PubMed
  23. Melanoma Res. 1997 Feb;7(1):43-8 - PubMed
  24. Mod Pathol. 2011 May;24(5):613-23 - PubMed
  25. J Clin Invest. 1989 Nov;84(5):1470-8 - PubMed
  26. J Cutan Pathol. 2007 Feb;34(2):139-45 - PubMed
  27. J Am Acad Dermatol. 2011 Aug;65(2):357-363 - PubMed
  28. Mod Pathol. 2012 Jun;25(6):828-37 - PubMed
  29. J Am Acad Dermatol. 1999 Dec;41(6):962-9 - PubMed
  30. Brain Res Bull. 1995;37(4):417-29 - PubMed
  31. Pathology. 1994 Jan;26(1):16-9 - PubMed
  32. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6458-62 - PubMed
  33. Mod Pathol. 1998 Aug;11(8):740-6 - PubMed
  34. J Am Acad Dermatol. 2003 Aug;49(2):255-63 - PubMed
  35. Melanoma Res. 2001 Dec;11(6):627-32 - PubMed
  36. Nucleic Acids Res. 1995 Jan 11;23(1):154-8 - PubMed
  37. Clin Cancer Res. 2004 Mar 1;10(5):1753-7 - PubMed
  38. Am J Surg Pathol. 2009 Dec;33(12):1783-8 - PubMed
  39. Front Biosci. 2002 May 01;7:d1356-68 - PubMed
  40. Anticancer Res. 2007 Sep-Oct;27(5A):3441-9 - PubMed
  41. Cancer. 1983 Mar 1;51(5):840-3 - PubMed
  42. J Clin Pathol. 2001 Mar;54(3):196-200 - PubMed
  43. Am J Clin Pathol. 1983 Mar;79(3):341-7 - PubMed
  44. J Mol Diagn. 2011 May;13(3):352-8 - PubMed
  45. Melanoma Res. 2003 Feb;13(1):45-9 - PubMed
  46. Am J Surg Pathol. 1982 Dec;6(8):715-27 - PubMed
  47. Cancer Res. 1993 Jun 15;53(12):2830-3 - PubMed
  48. J Natl Cancer Inst. 2006 Apr 5;98(7):472-82 - PubMed
  49. Int J Cancer. 2007 Jun 1;120(11):2439-44 - PubMed
  50. Semin Oncol. 2011 Dec;38(6):781-7 - PubMed
  51. Histochem J. 2000 Aug;32(8):475-81 - PubMed
  52. J Clin Oncol. 2001 Feb 1;19(3):824-31 - PubMed
  53. Clin Cancer Res. 2009 Oct 15;15(20):6404-11 - PubMed
  54. J Exp Clin Cancer Res. 2000 Sep;19(3):301-7 - PubMed
  55. Hum Pathol. 2001 Dec;32(12):1376-81 - PubMed
  56. J Clin Oncol. 2011 Jun 1;29(16):2199-205 - PubMed
  57. Curr Mol Med. 2013 Jan;13(1):24-57 - PubMed
  58. Pigment Cell Res. 2005 Oct;18(5):322-36 - PubMed
  59. Clin Cancer Res. 2010 Jul 1;16(13):3356-67 - PubMed
  60. BMC Cancer. 2010 Apr 14;10:140 - PubMed
  61. Cell. 1993 Jul 30;74(2):395-404 - PubMed
  62. Melanoma Res. 2008 Dec;18(6):412-9 - PubMed
  63. J Invest Dermatol. 2010 Aug;130(8):1971-87 - PubMed
  64. Am J Clin Pathol. 2010 Mar;133(3):370-9 - PubMed
  65. J Clin Oncol. 2001 Jan 15;19(2):577-83 - PubMed
  66. Am J Surg Pathol. 2011 Feb;35(2):243-52 - PubMed
  67. Clin Exp Dermatol. 2004 Nov;29(6):628-9 - PubMed
  68. Br J Dermatol. 2000 Aug;143(2):256-68 - PubMed
  69. Pigment Cell Melanoma Res. 2010 Feb;23(1):137-40 - PubMed
  70. Am J Dermatopathol. 2004 Oct;26(5):364-6 - PubMed
  71. J Natl Cancer Inst. 1990 Jan 3;82(1):4-6 - PubMed
  72. Cancer Res. 1996 May 1;56(9):2218-23 - PubMed
  73. Mod Pathol. 2010 Mar;23(3):413-9 - PubMed
  74. Mol Biol Cell. 2005 Nov;16(11):5356-72 - PubMed
  75. J Eur Acad Dermatol Venereol. 2007 May;21(5):669-77 - PubMed
  76. Clin Chem. 1988 Jul;34(7):1387-91 - PubMed
  77. Anticancer Res. 2000 Nov-Dec;20(6D):5041-4 - PubMed
  78. J Invest Dermatol. 2003 Oct;121(4):910-7 - PubMed
  79. Ann Surg Oncol. 2012 Feb;19(2):620-6 - PubMed
  80. Nat Rev Cancer. 2011 Nov 24;11(12):849-64 - PubMed
  81. Thromb Haemost. 1998 Jul;80(1):171-5 - PubMed
  82. Am J Surg Pathol. 2011 Aug;35(8):1146-50 - PubMed
  83. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6092-7 - PubMed
  84. Nat Rev Genet. 2011 Nov 18;12(12):861-74 - PubMed
  85. Br J Cancer. 2000 Nov;83(9):1216-22 - PubMed
  86. Biochem Biophys Res Commun. 1988 Aug 30;155(1):112-7 - PubMed
  87. N Engl J Med. 2011 Jun 30;364(26):2507-16 - PubMed
  88. Ann Surg Oncol. 2009 Dec;16(12):3455-62 - PubMed
  89. Nature. 2000 Aug 3;406(6795):536-40 - PubMed
  90. Br J Cancer. 2012 Jul 24;107(3):422-8 - PubMed
  91. J Clin Oncol. 2003 Mar 1;21(5):767-73 - PubMed
  92. J Clin Oncol. 1999 Jun;17(6):1891-6 - PubMed
  93. Cancer. 1993 Nov 15;72(10):3091-8 - PubMed
  94. Am J Surg Pathol. 2004 Jul;28(7):883-8 - PubMed
  95. J Cutan Pathol. 2009 Jul;36(7):753-9 - PubMed
  96. Neuroimmunomodulation. 2005;12(4):201-10 - PubMed
  97. J Cutan Pathol. 1983 Aug;10(4):225-37 - PubMed
  98. Am J Pathol. 1988 Jan;130(1):179-92 - PubMed
  99. Clin Chem. 2005 Jun;51(6):981-8 - PubMed
  100. J Biol Chem. 2010 Aug 27;285(35):27487-27498 - PubMed
  101. J Biol Chem. 1994 Aug 5;269(31):20126-33 - PubMed
  102. J Clin Oncol. 2007 Mar 20;25(9):1129-34 - PubMed
  103. Nature. 2002 Jun 27;417(6892):949-54 - PubMed
  104. Lancet. 1991 Nov 16;338(8777):1227-9 - PubMed
  105. J Biol Chem. 2000 Nov 3;275(44):34672-80 - PubMed
  106. Eur J Cancer. 2010 Aug;46(12):2285-94 - PubMed
  107. Clin Chim Acta. 2010 Sep 6;411(17-18):1319-24 - PubMed
  108. Melanoma Res. 2003 Aug;13(4):427-9 - PubMed
  109. Arch Dermatol Res. 2000 Dec;292(12):583-9 - PubMed
  110. J Clin Oncol. 2009 Jan 1;27(1):38-44 - PubMed
  111. Diagn Cytopathol. 2013 Feb;41(2):126-30 - PubMed
  112. Br J Cancer. 2006 Mar 27;94(6):835-41 - PubMed
  113. Mayo Clin Proc. 2011 Oct;86(10):981-90 - PubMed
  114. Br J Cancer. 2004 Aug 16;91(4):699-702 - PubMed
  115. J Invest Dermatol. 2005 Aug;125(2):312-7 - PubMed
  116. Br J Cancer. 2011 Nov 22;105(11):1726-32 - PubMed
  117. Am J Pathol. 2003 Jul;163(1):333-43 - PubMed
  118. Am J Surg Pathol. 1998 May;22(5):595-602 - PubMed
  119. J Med Chem. 2006 Jun 1;49(11):3136-42 - PubMed
  120. Am J Surg Pathol. 2001 Feb;25(2):205-11 - PubMed
  121. Ann N Y Acad Sci. 1983;420:261-6 - PubMed
  122. Trends Biochem Sci. 1996 Apr;21(4):134-40 - PubMed
  123. J Clin Oncol. 1996 May;14(5):1697-703 - PubMed
  124. Am J Dermatopathol. 1994 Feb;16(1):14-22 - PubMed
  125. Am J Surg Pathol. 2005 Mar;29(3):400-6 - PubMed
  126. Cancer. 2001 Oct 25;93(5):337-43 - PubMed
  127. Am J Pathol. 2004 Jan;164(1):193-203 - PubMed
  128. Adv Cancer Res. 2010;109:73-121 - PubMed
  129. J Invest Dermatol. 2008 Oct;128(10):2365-80 - PubMed
  130. Dermatol Surg. 2002 Aug;28(8):656-65 - PubMed
  131. Cancer Lett. 1998 Mar 13;125(1-2):35-8 - PubMed
  132. Keio J Med. 2008 Mar;57(1):57-64 - PubMed
  133. J Clin Invest. 2003 Jun;111(12):1805-12 - PubMed
  134. J Natl Cancer Inst. 2009 Apr 1;101(7):452-74 - PubMed
  135. Melanoma Res. 2001 Jun;11(3):291-6 - PubMed
  136. Pathol Oncol Res. 2002;8(3):183-7 - PubMed
  137. Biotechniques. 2008 Apr;44(5):619-26 - PubMed
  138. Traffic. 2002 Sep;3(9):678-93 - PubMed
  139. J Immunother. 2011 Oct;34(8):597-605 - PubMed
  140. Histopathology. 2001 Jan;38(1):68-72 - PubMed
  141. Am J Dermatopathol. 2008 Jun;30(3):228-32 - PubMed
  142. J Invest Dermatol. 2013 Mar;133(3):768-775 - PubMed
  143. Am J Pathol. 1999 Sep;155(3):731-8 - PubMed
  144. J Invest Dermatol. 2009 Jul;129(7):1740-51 - PubMed
  145. J Am Acad Dermatol. 2011 Dec;65(6):1152-60 - PubMed
  146. Melanoma Res. 2009 Feb;19(1):31-5 - PubMed
  147. FEBS Lett. 1989 Jan 2;242(2):237-9 - PubMed
  148. J Invest Dermatol. 2010 Aug;130(8):2062-70 - PubMed
  149. World J Surg Oncol. 2011 May 20;9:54 - PubMed
  150. Cancer Res. 1995 Sep 15;55(18):4140-5 - PubMed
  151. Anticancer Res. 2007 Jan-Feb;27(1B):595-9 - PubMed
  152. Am J Surg Pathol. 2001 Feb;25(2):197-204 - PubMed
  153. N Engl J Med. 2011 Jun 30;364(26):2517-26 - PubMed
  154. Br J Dermatol. 1998 Mar;138(3):426-30 - PubMed
  155. Clin Cancer Res. 2009 Nov 15;15(22):6987-92 - PubMed
  156. Am J Surg Pathol. 2012 Jun;36(6):808-17 - PubMed
  157. Cancer Res. 1989 Oct 1;49(19):5358-63 - PubMed
  158. Clin Cancer Res. 1996 Aug;2(8):1405-9 - PubMed
  159. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2474-9 - PubMed
  160. Am J Surg Pathol. 2001 Jan;25(1):51-7 - PubMed
  161. N Engl J Med. 2005 Nov 17;353(20):2135-47 - PubMed
  162. Melanoma Res. 1993 Oct;3(5):325-30 - PubMed
  163. Microsc Res Tech. 2003 Apr 15;60(6):540-51 - PubMed
  164. Int J Cancer. 2004 Sep 20;111(5):741-5 - PubMed
  165. Eur J Cancer. 2009 Jul;45(10):1807-14 - PubMed
  166. Mod Pathol. 2002 Dec;15(12):1288-93 - PubMed
  167. Nat Genet. 1996 Sep;14(1):50-4 - PubMed
  168. Am J Surg Pathol. 2009 Aug;33(8):1146-56 - PubMed
  169. Am J Surg Pathol. 2010 Feb;34(2):231-7 - PubMed
  170. J Clin Oncol. 2009 Dec 20;27(36):6199-206 - PubMed
  171. Clin Cancer Res. 2008 Jun 1;14(11):3401-7 - PubMed
  172. Am J Dermatopathol. 2005 Oct;27(5):401-6 - PubMed
  173. Br J Cancer. 2012 Jan 31;106(3):553-61 - PubMed
  174. Crit Rev Clin Lab Sci. 2011 Jul-Aug;48(4):155-70 - PubMed
  175. Arch Dermatol. 2012 Mar;148(3):335-44 - PubMed
  176. J Cutan Pathol. 2008 May;35(5):433-44 - PubMed
  177. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5915-9 - PubMed
  178. J Clin Oncol. 2009 Dec 1;27(34):5772-80 - PubMed
  179. Br J Cancer. 2003 Sep 1;89(5):877-85 - PubMed
  180. J Biol Chem. 1996 Jan 5;271(1):490-5 - PubMed
  181. Dermatol Surg. 2000 Aug;26(8):771-84 - PubMed
  182. J Exp Med. 1994 Jul 1;180(1):35-42 - PubMed
  183. Oncology. 1999;56(4):338-44 - PubMed
  184. Anticancer Res. 2001 Mar-Apr;21(2B):1311-6 - PubMed
  185. Cancer. 2005 Oct 15;104(8):1678-86 - PubMed
  186. J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e320-7 - PubMed
  187. Histopathology. 2000 May;36(5):387-402 - PubMed
  188. Plast Reconstr Surg. 2005 Feb;115(2):367-75 - PubMed
  189. BMC Cancer. 2006 Jan 11;6:8 - PubMed
  190. Int J Cancer. 2008 Nov 15;123(10):2370-6 - PubMed
  191. Cancer Res. 1997 Aug 1;57(15):3149-53 - PubMed
  192. J Clin Oncol. 2005 Nov 1;23(31):8048-56 - PubMed

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