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Onoyama M, Azuma K, Tsuka T, et al. Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model. Oncol Lett. 2014;7(4):1147-1150doi: 10.3892/ol.2014.1865.
Onoyama, M., Azuma, K., Tsuka, T., Imagawa, T., Osaki, T., Minami, S., Ogawa, N., & Okamoto, Y. (2014). Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model. Oncology letters, 7(4), 1147-1150. https://doi.org/10.3892/ol.2014.1865
Onoyama, Masaki, et al. "Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model." Oncology letters vol. 7,4 (2014): 1147-1150. doi: https://doi.org/10.3892/ol.2014.1865
Onoyama M, Azuma K, Tsuka T, Imagawa T, Osaki T, Minami S, Ogawa N, Okamoto Y. Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model. Oncol Lett. 2014 Apr;7(4):1147-1150. doi: 10.3892/ol.2014.1865. Epub 2014 Feb 10. PMID: 24944683; PMCID: PMC3961346.
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Oncol Lett. 2014 Apr;7(4):1147-1150. doi: 10.3892/ol.2014.1865. Epub 2014 Feb 10.

Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model.

Oncology letters

Masaki Onoyama, Kazuo Azuma, Takeshi Tsuka, Tomohiro Imagawa, Tomohiro Osaki, Saburo Minami, Nobuhiko Ogawa, Yoshiharu Okamoto

Affiliations

  1. The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan.
  2. Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan.
  3. Department of Veterinary Diagnostic Imaging, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan.
  4. Tokyo Iken Co., Ltd., Inashiro-shi, Tokyo 206-0802, Japan.
  5. Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan ; Department of Veterinary Neurology and Oncology, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan.

PMID: 24944683 PMCID: PMC3961346 DOI: 10.3892/ol.2014.1865

Abstract

The present study used indocyanine green (ICG) and a broadband light source apparatus [photodynamic hyperthermal therapy (PHT) group] in order to treat a colon 26 tumor-bearing mouse model. The other groups were administered either ICG alone (ICG group), light alone (light group) or no treatment (control group). Following the treatment, tumor growth was measured. Nine days after the treatment, the tumors were resected and histological and immunohistological examinations were performed. In the PHT group, the growth rates of the tumor tissues were significantly decreased compared with those observed in the other groups (P<0.05). The proportion of necrotic areas in the PHT and light groups were increased significantly compared with those observed in the ICG and control groups. However, there were no significant differences between the PHT and light groups. The proportion of Ki-67 in the PHT and light groups was less than that observed in the ICG and control groups. The number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling-positive cells in the PHT group was significantly increased compared with that observed in the other groups. These data indicate that PHT is effective

Keywords: colon 26; indocyanine green; photodynamic hyperthermal therapy; tumor

References

  1. Cancer Lett. 1995 Aug 1;94(2):125-31 - PubMed
  2. Cancer Lett. 1996 Jan 2;98(2):169-73 - PubMed
  3. J Vet Med Sci. 2012 Apr;74(4):465-72 - PubMed
  4. Breast. 2010 Jun;19(3):210-3 - PubMed
  5. J Vet Med Sci. 2012 May;74(5):545-51 - PubMed
  6. Photodiagnosis Photodyn Ther. 2009 Jun;6(2):117-21 - PubMed
  7. Radiat Res. 1977 Apr;70(1):224-35 - PubMed
  8. Cancer Lett. 1995 Jan 6;88(1):15-9 - PubMed
  9. Ophthalmology. 1994 Mar;101(3):529-33 - PubMed
  10. J Pharmacol Toxicol Methods. 1997 Jun;37(4):215-28 - PubMed
  11. Br J Cancer. 1999 May;80(3-4):360-3 - PubMed
  12. Prog Histochem Cytochem. 2003;38(3):275-339 - PubMed
  13. Surg Today. 2004;34(7):581-5 - PubMed
  14. Breast Cancer Res Treat. 2010 Jun;121(2):373-8 - PubMed
  15. Lasers Med Sci. 2002;17(4):272-9 - PubMed
  16. Histopathology. 2002 Jan;40(1):2-11 - PubMed
  17. Br J Cancer. 1998 Mar;77(6):1021-4 - PubMed

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