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Wang XL, Wang HW, Guo MX, et al. Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis. Photodiagnosis Photodyn Ther. 2007;4(2):88-93doi: 10.1016/j.pdpdt.2007.01.002.
Wang, X. L., Wang, H. W., Guo, M. X., & Huang, Z. (2007). Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis. Photodiagnosis and photodynamic therapy, 4(2), 88-93. https://doi.org/10.1016/j.pdpdt.2007.01.002
Wang, Xiu-Li, et al. "Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis." Photodiagnosis and photodynamic therapy vol. 4,2 (2007): 88-93. doi: https://doi.org/10.1016/j.pdpdt.2007.01.002
Wang XL, Wang HW, Guo MX, Huang Z. Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis. Photodiagnosis Photodyn Ther. 2007 Jun;4(2):88-93. doi: 10.1016/j.pdpdt.2007.01.002. Epub 2007 Feb 01. PMID: 25047339.
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Photodiagnosis Photodyn Ther. 2007 Jun;4(2):88-93. doi: 10.1016/j.pdpdt.2007.01.002. Epub 2007 Feb 01.

Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis.

Photodiagnosis and photodynamic therapy

Xiu-Li Wang, Hong-Wei Wang, Ming-Xia Guo, Zheng Huang

Affiliations

  1. Shanghai Skin Diseases and STD Hospital, Shanghai 200050, PR China.
  2. University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA.

PMID: 25047339 DOI: 10.1016/j.pdpdt.2007.01.002

Abstract

OBJECTIVE: To investigate the feasibility and efficacy of combination of imiquimod and 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of genital Bowenoid papulosis (BP).

MATERIALS AND METHODS: A total of 27 BP patients were randomized into two groups. Fifteen (12 male and 3 female, age 22-56 years old) were treated with topical application of 5% imiquimod cream (three times a week) and ALA-PDT (100J/cm(2) at 100mW/cm(2), once a week) for 1-4 times. For comparison, other 12 (6 male and 6 female, age 29-58 years old) were treated with CO2 laser vaporization as a control. Patients were followed up for 3-12 months. Biopsies were taken from BP lesions prior to treatment and tested for HPV-16 and HPV-18 DNA.

RESULTS: In combined therapy group, 60% (9/15) patients showed complete remission and only one recurred (11.1%) during follow up. Local side effects included mild erythema, edema, erosion and burning and/or stinging sensation. No systemic side effect was found. In CO2 laser vaporization group, 83.3% (10/12) patients showed complete remission. However, recurrence occurred in six patients (60.0%). Local side effects included mild to moderate edema, erosion, ulceration, delayed healing, prolonged pain and scarring. The difference of recurrence rate between two groups was statistically significant (P<0.05).

CONCLUSION: Topical application of imiquimod cream and ALA-PDT is safe, effective and associated with low recurrence and less side effect.

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