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Mahadimane PV, Vasudev V. Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica (Cairo). 2014;2014:703136doi: 10.1155/2014/703136.
Mahadimane, P. V., & Vasudev, V. (2014). Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica, 2014703136. https://doi.org/10.1155/2014/703136
Mahadimane, Periyapatna Vishwaprakash, and Vasudev, Venkateshaiah. "Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells." Scientifica vol. 2014 (2014): 703136. doi: https://doi.org/10.1155/2014/703136
Mahadimane PV, Vasudev V. Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica (Cairo). 2014;2014:703136. doi: 10.1155/2014/703136. Epub 2014 Jun 04. PMID: 24999435; PMCID: PMC4066937.
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Scientifica (Cairo). 2014;2014:703136. doi: 10.1155/2014/703136. Epub 2014 Jun 04.

Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells.

Scientifica

Periyapatna Vishwaprakash Mahadimane, Venkateshaiah Vasudev

Affiliations

  1. Department of Studies in Bioscience, Post-Graduate Centre, University of Mysore, Hemagangotri, Hassan, Karnataka 573220, India.

PMID: 24999435 PMCID: PMC4066937 DOI: 10.1155/2014/703136

Abstract

In order to investigate the presence of adaptive response in cancerous cells, two monofunctional alkylating agents, namely, ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS), were employed to treat Ehrlich ascites carcinoma (EAC) cells in vivo. Conditioning dose of 80 mg/kg body weight of EMS or 50 mg/kg body weight of MMS and challenging dose of 240 mg/kg body weight of EMS or 150 mg/kg body weight of MMS were selected by pilot toxicity studies. Conditioned EAC cells when challenged after 8 h time lag resulted in significant reduction in chromosomal aberrations compared to challenging dose of respective agents. As has been proved in earlier studies with normal organisms, even in cancerous cells (EAC), there is presence of adaptive response to methylating and ethylating agents. Furthermore, it is also interesting to note in the present studies that the methylating agent, MMS, is a stronger inducer of the adaptive response than the ethylating agent, EMS.

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