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Bugaj A, Kwitniewski M, Iani V, et al. Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice. Photodiagnosis Photodyn Ther. 2007;4(4):237-41doi: 10.1016/j.pdpdt.2007.08.001.
Bugaj, A., Kwitniewski, M., Iani, V., Juzeniene, A., Juzenas, P., Ma, L. W., & Moan, J. (2007). Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice. Photodiagnosis and photodynamic therapy, 4(4), 237-41. https://doi.org/10.1016/j.pdpdt.2007.08.001
Bugaj, Andrzej, et al. "Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice." Photodiagnosis and photodynamic therapy vol. 4,4 (2007): 237-41. doi: https://doi.org/10.1016/j.pdpdt.2007.08.001
Bugaj A, Kwitniewski M, Iani V, Juzeniene A, Juzenas P, Ma LW, Moan J. Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice. Photodiagnosis Photodyn Ther. 2007 Dec;4(4):237-41. doi: 10.1016/j.pdpdt.2007.08.001. Epub 2007 Nov 08. PMID: 25047558.
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Photodiagnosis Photodyn Ther. 2007 Dec;4(4):237-41. doi: 10.1016/j.pdpdt.2007.08.001. Epub 2007 Nov 08.

Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice.

Photodiagnosis and photodynamic therapy

Andrzej Bugaj, Mateusz Kwitniewski, Vladimir Iani, Asta Juzeniene, Petras Juzenas, Li Wei Ma, Johan Moan

Affiliations

  1. Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Montebello 0-310 Oslo, Norway.
  2. Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Montebello 0-310 Oslo, Norway; Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gda?sk, ul. Do Studzienki 38, 81-519 Gda?sk, Poland.
  3. Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Montebello 0-310 Oslo, Norway; Institute of Physics, University of Oslo, 0-316 Oslo, Norway.

PMID: 25047558 DOI: 10.1016/j.pdpdt.2007.08.001

Abstract

The fluorescence kinetics of a new photosensitizer for photodynamic therapy, di-l-arginine protoporphyrinate (PP(Arg)2), was studied in the skin of healthy mice. Furthermore, induction of necrosis in WiDr human colon adenocarcinoma xenografts in athymic nude mice was studied after photodynamic therapy (PDT) with PP(Arg)2. After intravenous administration of PP(Arg)2 maximal fluorescence was reached after 72h in normal mouse skin. Complete elimination of the drug from the mouse skin was not found even after 32 days. Exposure of WiDr tumours in mice to red light (λ=632nm, fluence 150J/cm(2), fluence rate 250mW/cm(2)) 24 and 72h after intravenous administration of 10mg/kg of PP(Arg)2 caused extensive tumour necrosis. Epidermal damage and infiltration of inflammatory cells was seen 24h after light exposure but not after 72h.

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