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Yang ZJ, Fu L, Zhang GW, et al. Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds. Asian-Australas J Anim Sci. 2013;26(11):1529-35doi: 10.5713/ajas.2013.13278.
Yang, Z. J., Fu, L., Zhang, G. W., Yang, Y., Chen, S. Y., Wang, J., & Lai, S. J. (2013). Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds. Asian-Australasian journal of animal sciences, 26(11), 1529-35. https://doi.org/10.5713/ajas.2013.13278
Yang, Zhi-Juan, et al. "Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds." Asian-Australasian journal of animal sciences vol. 26,11 (2013): 1529-35. doi: https://doi.org/10.5713/ajas.2013.13278
Yang ZJ, Fu L, Zhang GW, Yang Y, Chen SY, Wang J, Lai SJ. Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds. Asian-Australas J Anim Sci. 2013 Nov;26(11):1529-35. doi: 10.5713/ajas.2013.13278. PMID: 25049738; PMCID: PMC4093812.
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Asian-Australas J Anim Sci. 2013 Nov;26(11):1529-35. doi: 10.5713/ajas.2013.13278.

Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds.

Asian-Australasian journal of animal sciences

Zhi-Juan Yang, Lu Fu, Gong-Wei Zhang, Yu Yang, Shi-Yi Chen, Jie Wang, Song-Jia Lai

Affiliations

  1. Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.

PMID: 25049738 PMCID: PMC4093812 DOI: 10.5713/ajas.2013.13278

Abstract

The TBC1D1 plays a key role in body energy homeostasis by regulating the insulin-stimulated glucose uptake in skeletal muscle. The present study aimed to identify the association between genetic polymorphisms of TBC1D1 and body weight (BW) in rabbits. Among the total of 12 SNPs detected in all 20 exons, only one SNP was non-synonymous (c.214G>A. p.G72R) located in exon 1. c.214G>A was subsequently genotyped among 491 individuals from two rabbit breeds by the high-resolution melting method. Allele A was the predominant allele with frequencies of 0.7780 and 0.6678 in European white rabbit (EWR, n = 205) and New Zealand White rabbit (NZW, n = 286), respectively. The moderate polymorphism information content (0.250.05). Our results implied that the c.214G>A of TBC1D1 gene might be one of the candidate loci affecting the trait of 35 d BW in the rabbit.

Keywords: Growth Traits; High-resolution Melting; Polymorphism; Rabbit; TBC1D1

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