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Khoury G, Sheikh-Taha M. Effect of age and sex on warfarin dosing. Clin Pharmacol. 2014;6:103-6doi: 10.2147/CPAA.S66776.
Khoury, G., & Sheikh-Taha, M. (2014). Effect of age and sex on warfarin dosing. Clinical pharmacology : advances and applications, 6103-6. https://doi.org/10.2147/CPAA.S66776
Khoury, Ghada, and Sheikh-Taha, Marwan. "Effect of age and sex on warfarin dosing." Clinical pharmacology : advances and applications vol. 6 (2014): 103-6. doi: https://doi.org/10.2147/CPAA.S66776
Khoury G, Sheikh-Taha M. Effect of age and sex on warfarin dosing. Clin Pharmacol. 2014 Jul 12;6:103-6. doi: 10.2147/CPAA.S66776. eCollection 2014. PMID: 25050078; PMCID: PMC4103915.
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Clin Pharmacol. 2014 Jul 12;6:103-6. doi: 10.2147/CPAA.S66776. eCollection 2014.

Effect of age and sex on warfarin dosing.

Clinical pharmacology : advances and applications

Ghada Khoury, Marwan Sheikh-Taha

Affiliations

  1. School of Pharmacy, Lebanese American University, Byblos, Lebanon.
  2. Department of Pharmacy Practice, Lebanese American University, Byblos, Lebanon.

PMID: 25050078 PMCID: PMC4103915 DOI: 10.2147/CPAA.S66776

Abstract

OBJECTIVE: We examined the potential effect of sex and age on warfarin dosing in ambulatory adult patients.

METHODS: We conducted a retrospective chart review of patients attending an anticoagulation clinic. We included patients anticoagulated with warfarin for atrial fibrillation or venous thromboembolism who had a therapeutic international normalized ratio of 2-3 for 2 consecutive months. We excluded patients who had been on any drug that is known to have a major interaction with warfarin, smokers, and heavy alcohol consumers. Out of 340 screened medical records, 96 met the predetermined inclusion criteria. The primary outcome assessed was warfarin total weekly dose (TWD).

RESULTS: There was a statistically significant difference in the TWD among the ages (P<0.01); older patients required lower doses. However there was no statistically significant difference in the TWD between sexes (P=0.281).

CONCLUSION: Age was found to have a significant effect on warfarin dosing. Even though women did require a lower TWD than men, this observation was not statistically significant.

Keywords: INR; age; anticoagulation; vitamin K antagonists; warfarin

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