Display options
Share it on

Front Neurol. 2014 Jun 23;5:101. doi: 10.3389/fneur.2014.00101. eCollection 2014.

Reviving Intracranial Angioplasty and Stenting "SAMMPRIS and beyond".

Frontiers in neurology

Muhammad U Farooq, Firas Al-Ali, Jiangyong Min, Philip B Gorelick

Affiliations

  1. Division of Stroke and Vascular Neurology, Mercy Health Hauenstein Neurosciences at Saint Mary's , Grand Rapids, MI , USA.
  2. Center for Neuro and Spine, Akron General Medical Center , Akron, OH , USA.
  3. Division of Stroke and Vascular Neurology, Mercy Health Hauenstein Neurosciences at Saint Mary's , Grand Rapids, MI , USA ; Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine , Grand Rapids, MI , USA.

PMID: 25002858 PMCID: PMC4066298 DOI: 10.3389/fneur.2014.00101

Abstract

We review the methods and results of Stenting and Aggressive Medical Management for Preventing Recurrent Stroke (SAMMPRIS) and provide a critical review of its strengths and limitations. In SAMMPRIS, the aggressive medical treatment arm (AMT arm) did substantially better than the Wingspan Stenting plus aggressive medical management arm (WS+ arm). Complications in the first 30 days post intervention led to the disparity between treatment arms. A major contribution of SAMMPRIS was the added value that AMT and lifestyle change may provide, when compared to a precursor trial, Warfarin-Aspirin Symptomatic Intracranial Disease (WASID), designed to prevent stroke in persons with high-grade symptomatic intracranial occlusive disease, however, the results of neither of these two trials have ever been reproduced. On the other hand, we argue that technical limitations of the Wingspan stent system (WS System) and lack of an angioplasty only intervention arm may have led to a premature launch of the trial and early termination of the study. Future randomized trials with different devices and modified patient selection criteria are warranted.

Keywords: Wingspan stent; angioplasty; best medical therapy; intracranial stenosis; neurointervention; stenting

References

  1. Stroke. 1995 Jan;26(1):14-20 - PubMed
  2. Stroke Res Treat. 2013;2013:727842 - PubMed
  3. AJNR Am J Neuroradiol. 1998 Sep;19(8):1525-33 - PubMed
  4. Neurology. 2000 Aug 22;55(4):490-7 - PubMed
  5. N Engl J Med. 1991 Aug 15;325(7):445-53 - PubMed
  6. Stroke. 2010 Mar;41(3):494-8 - PubMed
  7. Neurology. 2006 Jun 27;66(12):1868-72 - PubMed
  8. Stroke. 2006 Apr;37(4):1016-20 - PubMed
  9. Stroke. 2011 Mar;42(3):675-80 - PubMed
  10. AMA Arch Neurol Psychiatry. 1951 Mar;65(3):346-77 - PubMed
  11. Circulation. 2006 Jan 31;113(4):555-63 - PubMed
  12. Rev Neurol Dis. 2006 Winter;3(1):8-18 - PubMed
  13. J Neurointerv Surg. 2013 Nov;5(6):528-33 - PubMed
  14. Neuroimaging Clin N Am. 2007 Aug;17(3):355-63, viii-ix - PubMed
  15. Neurosurgery. 2012 Jan;70(1):25-30; discussion 31 - PubMed
  16. N Engl J Med. 2011 Sep 15;365(11):993-1003 - PubMed
  17. Neurology. 1995 Aug;45(8):1488-93 - PubMed
  18. N Engl J Med. 2005 Mar 31;352(13):1305-16 - PubMed
  19. Stroke. 2007 Mar;38(3):881-7 - PubMed
  20. Neurosurgery. 2011 Jan;68(1):53-60; discussion 60-1 - PubMed
  21. Stroke. 2012 Feb;43(2):580-4 - PubMed
  22. Neurology. 2008 Apr 22;70(17):1518-24 - PubMed
  23. Eur J Vasc Endovasc Surg. 2010 Oct;40(4):499-506 - PubMed
  24. N Engl J Med. 2010 Jul 1;363(1):11-23 - PubMed
  25. Lancet. 1996 Jun 8;347(9015):1591-3 - PubMed
  26. Stroke. 1982 Nov-Dec;13(6):825-8 - PubMed
  27. N Engl J Med. 2011 Sep 15;365(11):1054-5 - PubMed
  28. J Neurosurg. 1999 Sep;91(3):415-23 - PubMed
  29. AJNR Am J Neuroradiol. 2011 Aug;32(7):1221-6 - PubMed
  30. AJNR Am J Neuroradiol. 2008 Apr;29(4):781-5 - PubMed
  31. AJNR Am J Neuroradiol. 1980 Jul-Aug;1(4):348-9 - PubMed
  32. J Stroke Cerebrovasc Dis. 2011 Jul-Aug;20(4):357-68 - PubMed
  33. Stroke. 2004 Dec;35(12):2832-6 - PubMed
  34. Neurology. 2007 Apr 10;68(15):1237; author reply 1237 - PubMed

Publication Types