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Lee IK. The role of pyruvate dehydrogenase kinase in diabetes and obesity. Diabetes Metab J. 2014;38(3):181-6doi: 10.4093/dmj.2014.38.3.181.
Lee, I. K. (2014). The role of pyruvate dehydrogenase kinase in diabetes and obesity. Diabetes & metabolism journal, 38(3), 181-6. https://doi.org/10.4093/dmj.2014.38.3.181
Lee, In-Kyu. "The role of pyruvate dehydrogenase kinase in diabetes and obesity." Diabetes & metabolism journal vol. 38,3 (2014): 181-6. doi: https://doi.org/10.4093/dmj.2014.38.3.181
Lee IK. The role of pyruvate dehydrogenase kinase in diabetes and obesity. Diabetes Metab J. 2014 Jun;38(3):181-6. doi: 10.4093/dmj.2014.38.3.181. PMID: 25003070; PMCID: PMC4083023.
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Diabetes Metab J. 2014 Jun;38(3):181-6. doi: 10.4093/dmj.2014.38.3.181.

The role of pyruvate dehydrogenase kinase in diabetes and obesity.

Diabetes & metabolism journal

In-Kyu Lee

Affiliations

  1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

PMID: 25003070 PMCID: PMC4083023 DOI: 10.4093/dmj.2014.38.3.181

Abstract

The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD(+)) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.

Keywords: Diabetes mellitus; Obesity; Pyruvate dehydrogenase (acetyl-transferring) kinase

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