Display options
Cite
Bruni A, Gala-Lopez B, Pepper AR, et al. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes. 2014;7:211-23doi: 10.2147/DMSO.S50789.
Bruni, A., Gala-Lopez, B., Pepper, A. R., Abualhassan, N. S., & Shapiro, A. J. (2014). Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes, metabolic syndrome and obesity : targets and therapy, 7211-23. https://doi.org/10.2147/DMSO.S50789
Bruni, Anthony, et al. "Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 7 (2014): 211-23. doi: https://doi.org/10.2147/DMSO.S50789
Bruni A, Gala-Lopez B, Pepper AR, Abualhassan NS, Shapiro AJ. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes. 2014 Jun 23;7:211-23. doi: 10.2147/DMSO.S50789. eCollection 2014. PMID: 25018643; PMCID: PMC4075233.
Copy Download .nbib Format: NLM
Share it on

Diabetes Metab Syndr Obes. 2014 Jun 23;7:211-23. doi: 10.2147/DMSO.S50789. eCollection 2014.

Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges.

Diabetes, metabolic syndrome and obesity : targets and therapy

Anthony Bruni, Boris Gala-Lopez, Andrew R Pepper, Nasser S Abualhassan, Am James Shapiro

Affiliations

  1. Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, AB, Canada.

PMID: 25018643 PMCID: PMC4075233 DOI: 10.2147/DMSO.S50789

Abstract

Islet transplantation is a well-established therapeutic treatment for a subset of patients with complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet transplant recipients since 1999 were insulin independent for >1 year. In 2000, the Edmonton group reported the achievement of insulin independence in seven consecutive patients, which in a collaborative team effort propagated expansion of clinical islet transplantation centers worldwide in an effort to ameliorate the consequences of this disease. To date, clinical islet transplantation has established improved success with insulin independence rates up to 5 years post-transplant with minimal complications. In spite of marked clinical success, donor availability and selection, engraftment, and side effects of immunosuppression remain as existing obstacles to be addressed to further improve this therapy. Clinical trials to improve engraftment, the availability of insulin-producing cell sources, as well as alternative transplant sites are currently under investigation to expand treatment. With ongoing experimental and clinical studies, islet transplantation continues to be an exciting and attractive therapy to treat type I diabetes mellitus with the prospect of shifting from a treatment for some to a cure for all.

Keywords: Edmonton Protocol; engraftment; immunosuppression; islet transplantation; type I diabetes mellitus

References

  1. Immunol Rev. 2003 Dec;196:219-36 - PubMed
  2. Transplantation. 1996 Apr 15;61(7):1047-53 - PubMed
  3. Diabetologia. 2005 May;48(5):906-12 - PubMed
  4. World J Transplant. 2013 Dec 24;3(4):48-53 - PubMed
  5. Nat Biotechnol. 2006 Nov;24(11):1392-401 - PubMed
  6. Transplant Proc. 2011 Nov;43(9):3201-4 - PubMed
  7. Transplant Proc. 1992 Dec;24(6):2863-4 - PubMed
  8. N Engl J Med. 2012 Oct 4;367(14):1332-40 - PubMed
  9. Transplantation. 2010 Dec 27;90(12):1595-601 - PubMed
  10. Diabetes. 2011 Jan;60(1):1-8 - PubMed
  11. Curr Opin Organ Transplant. 2011 Dec;16(6):627-31 - PubMed
  12. PLoS One. 2012;7(5):e37004 - PubMed
  13. Diabetes. 1989 Jun;38(6):779-83 - PubMed
  14. Nat Rev Endocrinol. 2009 Aug;5(8):444-52 - PubMed
  15. Curr Diab Rep. 2013 Oct;13(5):713-22 - PubMed
  16. J Immunol. 1997 Mar 15;158(6):2947-54 - PubMed
  17. Lancet. 2011 Jul 23;378(9788):319-27 - PubMed
  18. JAMA. 2007 Apr 11;297(14):1568-76 - PubMed
  19. Br J Surg. 2008 Dec;95(12):1449-61 - PubMed
  20. Transplantation. 2011 Apr 27;91(8):841-6 - PubMed
  21. Curr Opin Organ Transplant. 2011 Dec;16(6):620-6 - PubMed
  22. J Autoimmun. 1994 Dec;7(6):845-50 - PubMed
  23. J Endocrinol. 1999 Nov;163(2):181-90 - PubMed
  24. Diabetes. 2002 Jun;51(6):1779-84 - PubMed
  25. Diabetes. 1967 Jan;16(1):35-9 - PubMed
  26. Ann N Y Acad Sci. 2008 Dec;1150:190-6 - PubMed
  27. Diabetologia. 2011 Oct;54(10):2494-505 - PubMed
  28. Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:23-26 - PubMed
  29. N Engl J Med. 1988 Sep 8;319(10):599-604 - PubMed
  30. Diabetes. 2013 Nov;62(11):3656-7 - PubMed
  31. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):123-7 - PubMed
  32. J Am Coll Surg. 2005 Mar;200(3):353-61 - PubMed
  33. JAMA. 2013 Sep 25;310(12):1240-7 - PubMed
  34. Diabetes. 1985 Dec;34(12):1306-8 - PubMed
  35. J Leukoc Biol. 2005 May;77(5):587-97 - PubMed
  36. J Transplant. 2011;2011:594851 - PubMed
  37. Diabetologia. 1986 Sep;29(9):670-2 - PubMed
  38. Can Med Assoc J. 1922 Mar;12(3):141-6 - PubMed
  39. Transplant Proc. 1998 Mar;30(2):398-9 - PubMed
  40. Diabetes. 2001 Mar;50(3):489-95 - PubMed
  41. J Biomater Sci Polym Ed. 2002;13(5):579-90 - PubMed
  42. Transplant Proc. 1977 Mar;9(1):233-6 - PubMed
  43. Clin Immunol Immunopathol. 1995 Jul;76(1 Pt 1):90-5 - PubMed
  44. Semin Intervent Radiol. 2012 Jun;29(2):90-8 - PubMed
  45. Diabetes. 2006 May;55(5):1361-8 - PubMed
  46. Diabetes. 2006 Jul;55(7):1907-14 - PubMed
  47. Cell Transplant. 2011;20(10):1641-7 - PubMed
  48. Cell Transplant. 2006;15(2):181-5 - PubMed
  49. Transplantation. 2011 Feb 15;91(3):373-8 - PubMed
  50. Cell Transplant. 2012;21(1):61-71 - PubMed
  51. Diabetes. 1989 Jan;38 Suppl 1:140-2 - PubMed
  52. Diabetologia. 1992 Aug;35(8):735-42 - PubMed
  53. Xenotransplantation. 2008 Jul-Aug;15(4):225-34 - PubMed
  54. Nat Biotechnol. 2008 Apr;26(4):443-52 - PubMed
  55. Int J Endocrinol. 2012;2012:396524 - PubMed
  56. Transplant Proc. 2006 Nov;38(9):3039-40 - PubMed
  57. J Transplant. 2011;2011:783168 - PubMed
  58. Diabetes Obes Metab. 2006 Jan;8(1):1-7 - PubMed
  59. Clin Dev Immunol. 2013;2013:352315 - PubMed
  60. Transplantation. 1994 Mar 27;57(6):954-8 - PubMed
  61. N Engl J Med. 2007 Jun 28;356(26):2754-5 - PubMed
  62. Diabetes. 2005 Jul;54(7):2060-9 - PubMed
  63. J Transplant. 2011;2011:979527 - PubMed
  64. Endocrinology. 2012 Mar;153(3):1116-28 - PubMed
  65. Transplantation. 1995 Mar 15;59(5):689-94 - PubMed
  66. Am J Transplant. 2005 Jan;5(1):1-2 - PubMed
  67. Diabetes Care. 2012 Jul;35(7):1436-45 - PubMed
  68. Cell Transplant. 1999 May-Jun;8(3):285-92 - PubMed
  69. Cell Transplant. 2003;12(4):407-12 - PubMed
  70. Clin Sci (Lond). 2006 Jun;110(6):611-25 - PubMed
  71. Transplantation. 2010 Oct 15;90(7):740-7 - PubMed
  72. Transplantation. 2000 Mar 15;69(5):761-6 - PubMed
  73. Transplantation. 2004 Nov 15;78(9):1367-75 - PubMed
  74. Am J Transplant. 2008 Mar;8(3):701-6 - PubMed
  75. Surgery. 1973 Jul;74(1):91-9 - PubMed
  76. Cell Transplant. 2007;16(1):1-8 - PubMed
  77. JAMA. 2005 Feb 16;293(7):830-5 - PubMed
  78. Am J Health Syst Pharm. 2011 Feb 1;68(3):211-8 - PubMed
  79. Cell Transplant. 2013;22(8):1463-76 - PubMed
  80. Diabetologia. 2010 Apr;53(4):614-23 - PubMed
  81. Transplantation. 2010 Aug 15;90(3):238-43 - PubMed
  82. N Engl J Med. 2000 Jul 27;343(4):230-8 - PubMed
  83. PLoS One. 2013;8(2):e57046 - PubMed
  84. Am J Transplant. 2004 Mar;4(3):295-8 - PubMed
  85. Transplantation. 1989 May;47(5):761-6 - PubMed
  86. Pharm Res. 2004 Jan;21(1):15-25 - PubMed
  87. Transplantation. 2010 Feb 27;89(4):465-71 - PubMed
  88. Curr Diab Rep. 2010 Oct;10(5):332-7 - PubMed
  89. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8 - PubMed
  90. Histochem Cell Biol. 2012 Jun;137(6):801-10 - PubMed
  91. Lancet. 1981 Sep 19;2(8247):631-2 - PubMed
  92. Br Med J (Clin Res Ed). 1987 Aug 1;295(6593):288-90 - PubMed
  93. J Nucl Med. 2013 Feb;54(2):244-51 - PubMed
  94. Transplant Proc. 2005 Mar;37(2):1309-10 - PubMed
  95. Transplantation. 2004 Sep 27;78(6):880-5 - PubMed
  96. Nat Med. 2003 Sep;9(9):1202-8 - PubMed
  97. Transplantation. 1973 Dec;16(6):686-9 - PubMed
  98. Cell Tissue Bank. 2001;2(4):217-24 - PubMed
  99. Nature. 1990 Sep 13;347(6289):151-6 - PubMed
  100. Int J Mol Med. 2003 Dec;12(6):851-4 - PubMed
  101. J Exp Med. 2005 Oct 3;202(7):913-8 - PubMed
  102. Transplantation. 2010 Nov 27;90(10):1054-62 - PubMed
  103. Diabetologia. 2008 Feb;51(2):227-32 - PubMed
  104. Nat Med. 1996 Dec;2(12):1348-53 - PubMed
  105. Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):533-42 - PubMed
  106. Transplantation. 2008 Jul 27;86(2):364-6 - PubMed
  107. Curr Diab Rep. 2013 Oct;13(5):745-55 - PubMed
  108. Transplantation. 1994 Jun 27;57(12):1804-10 - PubMed

Publication Types