Display options
Cite
Ostendorf BN, Jehn CF, Vuong LG, et al. Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. Springerplus. 2014;3:278doi: 10.1186/2193-1801-3-278.
Ostendorf, B. N., Jehn, C. F., Vuong, L. G., Nogai, H., Hemmati, P. G., Gebauer, B., Penack, O., Blau, I. W., Anagnostopoulos, I., & Arnold, R. (2014). Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. SpringerPlus, 3278. https://doi.org/10.1186/2193-1801-3-278
Ostendorf, Benjamin Nils, et al. "Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report." SpringerPlus vol. 3 (2014): 278. doi: https://doi.org/10.1186/2193-1801-3-278
Ostendorf BN, Jehn CF, Vuong LG, Nogai H, Hemmati PG, Gebauer B, Penack O, Blau IW, Anagnostopoulos I, Arnold R. Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. Springerplus. 2014 Jun 02;3:278. doi: 10.1186/2193-1801-3-278. eCollection 2014. PMID: 25019038; PMCID: PMC4085278.
Copy Download .nbib Format: NLM
Share it on

Springerplus. 2014 Jun 02;3:278. doi: 10.1186/2193-1801-3-278. eCollection 2014.

Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report.

SpringerPlus

Benjamin Nils Ostendorf, Christian Friedrich Jehn, Lam Giang Vuong, Hendrik Nogai, Philipp Guido Hemmati, Bernhard Gebauer, Olaf Penack, Igor Wolfgang Blau, Ioannis Anagnostopoulos, Renate Arnold

Affiliations

  1. Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany.
  2. Department of Radiology, Charité University Medicine, Berlin, Germany.
  3. Institute of Pathology, Charité University Medicine, Berlin, Germany.

PMID: 25019038 PMCID: PMC4085278 DOI: 10.1186/2193-1801-3-278

Abstract

BACKGROUND: Allogeneic stem cell transplant recipients are prone to infections by various organisms. Tuberculosis (TB) represents a rare infectious complication, especially in countries non-endemic for TB.

CASE REPORT: Here, we report the case of a German patient with exposure to TB decades before he was diagnosed with disseminated TB as well as synchronous Epstein-Barr virus associated lymphoproliferative disorder and cytomegalovirus infection after allogeneic stem cell transplantation for refractory acute myeloid leukemia. Tuberculostatic and virostatic therapy was administered and the patient could be discharged with no apparent signs of infection two weeks after initiation of therapy.

CONCLUSION: This case illustrates the need for awareness of mycobacterial infections in patients from non-endemic regions undergoing stem cell transplantation even if other reasons for fever are present.

Keywords: Allogeneic stem cell transplantation; Cytomegalovirus; Epstein-Barr virus; Post-transplant lymphoproliferative disorder; Tuberculosis

References

  1. Hematol Oncol. 2002 Jun;20(2):51-62 - PubMed
  2. Int J Infect Dis. 2010 Sep;14 Suppl 3:e187-91 - PubMed
  3. Am J Respir Crit Care Med. 1998 Oct;158(4):1173-7 - PubMed
  4. Nat Rev Immunol. 2001 Oct;1(1):75-82 - PubMed
  5. Bone Marrow Transplant. 2005 Oct;36(8):741-3 - PubMed
  6. Transpl Infect Dis. 2013 Feb;15(1):104-9 - PubMed
  7. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):679-91 - PubMed
  8. Clin Infect Dis. 2004 May 1;38(9):1229-36 - PubMed

Publication Types