Display options
Cite
Holmboe S, Andersen A, Vildbrad MD, et al. Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation. Pulm Circ. 2013;3(4):870-9doi: 10.1086/674760.
Holmboe, S., Andersen, A., Vildbrad, M. D., Nielsen, J. M., Ringgaard, S., & Nielsen-Kudsk, J. E. (2013). Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation. Pulmonary circulation, 3(4), 870-9. https://doi.org/10.1086/674760
Holmboe, Sarah, et al. "Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation." Pulmonary circulation vol. 3,4 (2013): 870-9. doi: https://doi.org/10.1086/674760
Holmboe S, Andersen A, Vildbrad MD, Nielsen JM, Ringgaard S, Nielsen-Kudsk JE. Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation. Pulm Circ. 2013 Dec;3(4):870-9. doi: 10.1086/674760. PMID: 25006403; PMCID: PMC4070825.
Copy Download .nbib Format: NLM
Share it on

Pulm Circ. 2013 Dec;3(4):870-9. doi: 10.1086/674760.

Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation.

Pulmonary circulation

Sarah Holmboe, Asger Andersen, Mads D Vildbrad, Jan M Nielsen, Steffen Ringgaard, Jens E Nielsen-Kudsk

Affiliations

  1. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  2. Magnetic Resonance Research Centre, Aarhus University Hospital, Aarhus, Denmark.

PMID: 25006403 PMCID: PMC4070825 DOI: 10.1086/674760

Abstract

Right heart function is an important predictor of morbidity and mortality in patients suffering from pulmonary arterial hypertension and congenital heart diseases. We investigated whether the prostacyclin analog iloprost has a direct inotropic effect in the pressure-overloaded hypertrophic and dysfunctional right ventricle (RV). Rats were randomized to monocrotaline injection (60 mg/kg; [Formula: see text]), pulmonary trunk banding (PTB; [Formula: see text]), or a sham operation ([Formula: see text]). RV function was evaluated with magnetic resonance imaging, echocardiography, and invasive pressure measurements at baseline, after intravenous administration of placebo, iloprost 10 ng/kg/min, or iloprost 100 ng/kg/min (Ilo100). Infusion of Ilo100 induced a [Formula: see text] ([Formula: see text]) increase in stroke volume in the sham group and a [Formula: see text] ([Formula: see text]) increase in the PTB group. RV [Formula: see text] was elevated by [Formula: see text] ([Formula: see text]) in the sham group and by [Formula: see text] ([Formula: see text]) in the PTB group. An elevation in cardiac output of [Formula: see text] ([Formula: see text]) and an [Formula: see text] ([Formula: see text]) increase in RV systolic pressure were found in the PTB group. Iloprost caused a decrease in mean arterial blood pressure (MAP) in all groups of animals. An equal reduction in MAP induced by the arterial vasodilator nitroprusside did not improve any of the measured parameters of RV function. We conclude that iloprost has inotropic properties directly improving ventricular function in the hypertrophic and dysfunctional right heart of the rat.

Keywords: heart failure; inotropy; prostacyclin; pulmonary hypertension; right heart

References

  1. Eur J Pharmacol. 2011 Mar 11;654(3):258-65 - PubMed
  2. J Appl Physiol (1985). 2007 Jul;103(1):287-95 - PubMed
  3. Circ Res. 2004 Apr 30;94(8):1101-8 - PubMed
  4. Eur J Pharmacol. 2012 Jul 5;686(1-3):66-73 - PubMed
  5. Life Sci. 1978 Jun 19;22(23):2079-85 - PubMed
  6. Crit Care. 2008;12(5):R113 - PubMed
  7. J Heart Lung Transplant. 1993 Mar-Apr;12(2):179-84 - PubMed
  8. Circulation. 2006 Oct 24;114(17):1883-91 - PubMed
  9. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93 - PubMed
  10. J Vet Med Sci. 1994 Aug;56(4):651-5 - PubMed
  11. Eur Surg Res. 2005 Jan-Feb;37(1):9-17 - PubMed
  12. J Thorac Cardiovasc Surg. 2003 Nov;126(5):1434-41 - PubMed
  13. J Cardiothorac Vasc Anesth. 1995 Dec;9(6):641-6 - PubMed
  14. Eur Heart J. 2009 Oct;30(20):2493-537 - PubMed
  15. Circulation. 2009 Nov 17;120(20):1951-60 - PubMed
  16. Curr Opin Cardiol. 2010 Mar;25(2):131-40 - PubMed
  17. Experientia. 1995 Sep 29;51(9-10):941-4 - PubMed
  18. Br J Clin Pract. 1990 Jun;44(6):231-4 - PubMed
  19. Am J Cardiol. 2000 Apr 1;85(7):837-42 - PubMed
  20. J Am Soc Echocardiogr. 2006 Oct;19(10):1272-9 - PubMed
  21. Chin Med J (Engl). 2012 Aug;125(16):2826-31 - PubMed
  22. Intensive Care Med. 2003 Sep;29(9):1574-83 - PubMed
  23. Eur J Heart Fail. 2008 Dec;10(12):1158-65 - PubMed
  24. Am J Respir Crit Care Med. 2007 Apr 15;175(8):846-50 - PubMed
  25. Heart. 2006 Apr;92 Suppl 1:i27-38 - PubMed
  26. Circulation. 2010 Jul 13;122(2):156-63 - PubMed
  27. Br J Pharmacol. 2007 Jul;151(6):779-86 - PubMed

Publication Types