Display options
Cite
Gajra B, Pandya SS, Singh S, et al. Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design. J Drug Deliv. 2014;2014:305863doi: 10.1155/2014/305863.
Gajra, B., Pandya, S. S., Singh, S., & Rabari, H. A. (2014). Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design. Journal of drug delivery, 2014305863. https://doi.org/10.1155/2014/305863
Gajra, Balaram, et al. "Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design." Journal of drug delivery vol. 2014 (2014): 305863. doi: https://doi.org/10.1155/2014/305863
Gajra B, Pandya SS, Singh S, Rabari HA. Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design. J Drug Deliv. 2014;2014:305863. doi: 10.1155/2014/305863. Epub 2014 Jun 10. PMID: 25006462; PMCID: PMC4071986.
Copy Download .nbib Format: NLM
Share it on

J Drug Deliv. 2014;2014:305863. doi: 10.1155/2014/305863. Epub 2014 Jun 10.

Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design.

Journal of drug delivery

Balaram Gajra, Saurabh S Pandya, Sanjay Singh, Haribhai A Rabari

Affiliations

  1. Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa, Petlad Taluka, Anand District, Gujarat State 388421, India.
  2. Shree Krishna Institute of Pharmacy, Krishna Campus, Shankhalpur, Bechraji Taluka, Mehsana District, Gujarat State 384210, India.
  3. Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh State 221005, India.
  4. L.M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat State 380009, India.

PMID: 25006462 PMCID: PMC4071986 DOI: 10.1155/2014/305863

Abstract

The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and "k" of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours.

References

  1. Eur J Pharm Sci. 2009 Mar 2;36(4-5):591-601 - PubMed
  2. Curr Drug Deliv. 2008 Apr;5(2):133-41 - PubMed
  3. Eur J Pharm Sci. 2002 Aug;16(3):193-9 - PubMed
  4. Pharm Res. 1989 Apr;6(4):338-41 - PubMed
  5. Colloids Surf B Biointerfaces. 2013 Nov 1;111:755-63 - PubMed
  6. J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):144-50 - PubMed
  7. Int J Pharm. 2004 May 19;276(1-2):59-66 - PubMed
  8. Pak J Pharm Sci. 2009 Apr;22(2):193-8 - PubMed
  9. Int J Pharm. 2003 Oct 2;264(1-2):1-14 - PubMed
  10. Eur J Pharm Biopharm. 2000 Nov;50(3):337-43 - PubMed
  11. Pharm Dev Technol. 2000;5(3):339-46 - PubMed
  12. Pharm Dev Technol. 1997 May;2(2):161-70 - PubMed
  13. Drug Dev Ind Pharm. 2003 Mar;29(3):321-37 - PubMed
  14. Int J Pharm. 2000 Jul 20;202(1-2):21-8 - PubMed
  15. Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2491-5 - PubMed
  16. Drug Dev Ind Pharm. 1999 Feb;25(2):247-51 - PubMed
  17. J Pharm Sci. 1962 Jan;51:77-83 - PubMed
  18. Int J Gynaecol Obstet. 2000 Dec;71 Suppl 1:S47-52 - PubMed
  19. Drug Dev Ind Pharm. 2002 Apr;28(4):431-42 - PubMed
  20. J Chemother. 2008 Jun;20(3):336-40 - PubMed
  21. J Pharm Pharmacol. 2009 May;61(5):559-67 - PubMed
  22. Drug Dev Ind Pharm. 2003 Aug;29(7):757-65 - PubMed
  23. Drug Dev Ind Pharm. 2003 May;29(5):565-74 - PubMed
  24. J Control Release. 1999 Mar 29;58(2):177-87 - PubMed
  25. Int J Pharm. 2007 May 24;336(2):263-8 - PubMed
  26. Int J Pharm. 2000 Aug 10;203(1-2):179-92 - PubMed
  27. J Pharm Pharmacol. 2007 Aug;59(8):1057-64 - PubMed
  28. Eur J Pharm Biopharm. 1999 Nov;48(3):217-24 - PubMed
  29. AAPS PharmSciTech. 2008;9(2):660-7 - PubMed

Publication Types