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Sun Z, Wang X. Case report of refractory tardive dystonia induced by olanzapine. Shanghai Arch Psychiatry. 2014;26(1):51-3doi: 10.3969/j.issn.1002-0829.2014.01.008.
Sun, Z., & Wang, X. (2014). Case report of refractory tardive dystonia induced by olanzapine. Shanghai archives of psychiatry, 26(1), 51-3. https://doi.org/10.3969/j.issn.1002-0829.2014.01.008
Sun, Zhenxiao, and Wang, Xiangli. "Case report of refractory tardive dystonia induced by olanzapine." Shanghai archives of psychiatry vol. 26,1 (2014): 51-3. doi: https://doi.org/10.3969/j.issn.1002-0829.2014.01.008
Sun Z, Wang X. Case report of refractory tardive dystonia induced by olanzapine. Shanghai Arch Psychiatry. 2014 Feb;26(1):51-3. doi: 10.3969/j.issn.1002-0829.2014.01.008. PMID: 25114482; PMCID: PMC4118003.
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Shanghai Arch Psychiatry. 2014 Feb;26(1):51-3. doi: 10.3969/j.issn.1002-0829.2014.01.008.

Case report of refractory tardive dystonia induced by olanzapine.

Shanghai archives of psychiatry

Zhenxiao Sun, Xiangli Wang

Affiliations

  1. Linyi Mental Health Center, Linyi, Shandong Province, China.

PMID: 25114482 PMCID: PMC4118003 DOI: 10.3969/j.issn.1002-0829.2014.01.008

Abstract

SUMMARY: Tardive dystonia (TDt), a cluster of extrapyramidal symptoms that are caused by long-term use of antipsychotic medication, is characterized by difficulty in autonomic movements of skeletal (voluntary) muscles and consequent deformations of the body. TDt is rarely seen among patients taking olanzapine, but olanzapine was the precipitating antipsychotic medication in this 22-year old male patient with schizophrenia who developed lip puckering, persistent involuntary torticollis, muscular pain, axial dystonia and unstable gait after taking a standard dose of olanzapine regularly for about one year. His symptoms did not resolve after his olanzapine was stopped. Four months of treatment with clozapine combined with magnesium valproate, vitamin E, tiapride, and lorazepam did not lead to any improvement in the dystonia.

Keywords: movement disorders/adverse effects; olanzapine; schizophrenia

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