Display options
Cite
Cipollini M, Landi S, Gemignani F. MicroRNA binding site polymorphisms as biomarkers in cancer management and research. Pharmgenomics Pers Med. 2014;7:173-91doi: 10.2147/PGPM.S61693.
Cipollini, M., Landi, S., & Gemignani, F. (2014). MicroRNA binding site polymorphisms as biomarkers in cancer management and research. Pharmacogenomics and personalized medicine, 7173-91. https://doi.org/10.2147/PGPM.S61693
Cipollini, Monica, et al. "MicroRNA binding site polymorphisms as biomarkers in cancer management and research." Pharmacogenomics and personalized medicine vol. 7 (2014): 173-91. doi: https://doi.org/10.2147/PGPM.S61693
Cipollini M, Landi S, Gemignani F. MicroRNA binding site polymorphisms as biomarkers in cancer management and research. Pharmgenomics Pers Med. 2014 Jul 23;7:173-91. doi: 10.2147/PGPM.S61693. eCollection 2014. PMID: 25114582; PMCID: PMC4126202.
Copy Download .nbib Format: NLM
Share it on

Pharmgenomics Pers Med. 2014 Jul 23;7:173-91. doi: 10.2147/PGPM.S61693. eCollection 2014.

MicroRNA binding site polymorphisms as biomarkers in cancer management and research.

Pharmacogenomics and personalized medicine

Monica Cipollini, Stefano Landi, Federica Gemignani

Affiliations

  1. Department of Biology, University of Pisa, Pisa, Italy.

PMID: 25114582 PMCID: PMC4126202 DOI: 10.2147/PGPM.S61693

Abstract

MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie several human diseases. Single nucleotide polymorphisms of transcripts may modulate the posttranscriptional regulation of gene expression by miRNAs and explain interindividual variability in cancer risk and in chemotherapy response. On the basis of recent association studies published in the literature, the present review mainly summarizes the potential role of miRNAs as molecular biomarkers for disease susceptibility, diagnosis, prognosis, and drug-response prediction in tumors. Many clues suggest a role for polymorphisms within the 3' untranslated regions of KRAS rs61764370, SET8 rs16917496, and MDM4 rs4245739 as SNPs in miRNA binding sites highly promising in the biology of human cancer. However, more studies are needed to better characterize the composite spectrum of genetic determinants for future use of markers in risk prediction and clinical management of diseases, heading toward personalized medicine.

Keywords: 3′-UTR target binding site; biomarkers; cancer risk; miRSNP

References

  1. Haematologica. 2013 Jun;98(6):913-7 - PubMed
  2. Ann Oncol. 2013 Oct;24 Suppl 6:vi51-6 - PubMed
  3. Clin Cancer Res. 2013 Jan 1;19(1):34-41 - PubMed
  4. Mol Biol Rep. 2012 Jan;39(1):369-73 - PubMed
  5. Nat Genet. 2005 May;37(5):495-500 - PubMed
  6. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13653-8 - PubMed
  7. Nature. 2005 Feb 17;433(7027):769-73 - PubMed
  8. J Biol Chem. 2002 Oct 18;277(42):39926-36 - PubMed
  9. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3300-5 - PubMed
  10. Eur Cytokine Netw. 2008 Dec;19(4):204-10 - PubMed
  11. Carcinogenesis. 2012 Feb;33(2):338-47 - PubMed
  12. Mol Cell Biol. 2009 Apr;29(8):2278-95 - PubMed
  13. Cancer Lett. 2012 Dec 31;327(1-2):73-89 - PubMed
  14. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3116-23 - PubMed
  15. PLoS One. 2013 Oct 11;8(10):e77024 - PubMed
  16. PLoS One. 2012;7(12):e51301 - PubMed
  17. Cancer Chemother Pharmacol. 2012 Mar;69(3):723-31 - PubMed
  18. Exp Ther Med. 2012 Apr;3(4):689-692 - PubMed
  19. J Immunol. 2012 Feb 15;188(4):1573-7 - PubMed
  20. PLoS Biol. 2004 Nov;2(11):e363 - PubMed
  21. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W696-700 - PubMed
  22. Carcinogenesis. 2012 Nov;33(11):2147-54 - PubMed
  23. World J Gastroenterol. 2008 Jul 21;14(27):4300-8 - PubMed
  24. Eur J Cardiothorac Surg. 2012 Jun;41(6):e173-81 - PubMed
  25. Tumour Biol. 2014 Jan;35(1):295-301 - PubMed
  26. Biochem Biophys Res Commun. 2013 Jan 11;430(2):529-34 - PubMed
  27. Tumour Biol. 2013 Oct;34(5):3159-63 - PubMed
  28. J Biol Chem. 2007 Jul 13;282(28):20053-7 - PubMed
  29. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7475-9 - PubMed
  30. PLoS One. 2011;6(6):e21726 - PubMed
  31. Cancer Res. 2012 Mar 15;72(6):1467-77 - PubMed
  32. Carcinogenesis. 2013 Oct;34(10):2292-9 - PubMed
  33. J Clin Oncol. 2009 Aug 10;27(23):3757-63 - PubMed
  34. Genes Dev. 2004 May 15;18(10):1165-78 - PubMed
  35. Breast Cancer Res Treat. 2011 Jul;128(1):79-84 - PubMed
  36. J Cell Sci. 2003 Jul 15;116(Pt 14):2975-86 - PubMed
  37. Breast Cancer Res Treat. 2013 Jul;140(1):151-7 - PubMed
  38. Mol Biol Rep. 2013 May;40(5):3493-502 - PubMed
  39. J Cell Sci. 2005 May 15;118(Pt 10):2085-92 - PubMed
  40. Nat Cell Biol. 2010 Nov;12(11):1086-93 - PubMed
  41. Carcinogenesis. 2012 Mar;33(3):581-6 - PubMed
  42. Cancer Res. 1980 Apr;40(4):998-1001 - PubMed
  43. Cell Cycle. 2008 Apr 1;7(7):853-8 - PubMed
  44. Histopathology. 2013 Aug;63(2):225-33 - PubMed
  45. PLoS One. 2012;7(6):e40127 - PubMed
  46. PLoS Genet. 2007 Mar 16;3(3):e42 - PubMed
  47. Cancer Invest. 1997;15(1):8-17 - PubMed
  48. Carcinogenesis. 2009 Jun;30(6):1003-7 - PubMed
  49. Carcinogenesis. 2008 Mar;29(3):579-84 - PubMed
  50. Mol Carcinog. 2014 Apr;53(4):280-5 - PubMed
  51. Zhonghua Zhong Liu Za Zhi. 2012 Nov;34(11):835-7 - PubMed
  52. Prostate Cancer Prostatic Dis. 2013 Dec;16(4):308-14 - PubMed
  53. Blood. 2003 Nov 15;102(10):3727-36 - PubMed
  54. Carcinogenesis. 2008 Jul;29(7):1306-11 - PubMed
  55. Pharmacogenet Genomics. 2013 Mar;23(3):142-7 - PubMed
  56. World J Gastroenterol. 2011 Feb 21;17(7):932-7 - PubMed
  57. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  58. Cancer Res. 2010 Dec 1;70(23):9641-9 - PubMed
  59. Cancer. 2012 Oct 1;118(19):4670-80 - PubMed
  60. Endocr Relat Cancer. 2013 Nov 04;20(6):861-74 - PubMed
  61. Carcinogenesis. 2011 Nov;32(11):1668-74 - PubMed
  62. Cancer Epidemiol Biomarkers Prev. 2001 Aug;10(8):823-9 - PubMed
  63. Carcinogenesis. 2009 Jan;30(1):59-64 - PubMed
  64. BMC Cancer. 2012 Nov 20;12:534 - PubMed
  65. BMC Cancer. 2010 Mar 10;10:89 - PubMed
  66. PLoS One. 2013 Aug 16;8(8):e72197 - PubMed
  67. Clin Cancer Res. 2011 Dec 15;17(24):7723-31 - PubMed
  68. Nat Genet. 2006 Dec;38(12):1452-6 - PubMed
  69. Clin Cancer Res. 2006 Dec 15;12(24):7347-52 - PubMed
  70. Carcinogenesis. 2012 Jul;33(7):1346-51 - PubMed
  71. Curr Biol. 2001 Oct 16;11(20):1600-5 - PubMed
  72. Clin Cancer Res. 2010 Jul 15;16(14):3713-20 - PubMed
  73. Fam Cancer. 2006;5(1):89-93 - PubMed
  74. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10737-42 - PubMed
  75. PLoS One. 2013 May 28;8(5):e64973 - PubMed
  76. Carcinogenesis. 2008 Jul;29(7):1394-9 - PubMed
  77. Carcinogenesis. 2012 Dec;33(12):2377-83 - PubMed
  78. Carcinogenesis. 2009 Dec;30(12):2064-9 - PubMed
  79. CA Cancer J Clin. 2005 Jan-Feb;55(1):45-54; quiz 57 - PubMed
  80. BMJ. 2000 Sep 9;321(7261):624-8 - PubMed
  81. Cancer Res. 2010 Aug 15;70(16):6509-15 - PubMed
  82. Can J Urol. 2011 Oct;18(5):5875-83 - PubMed
  83. Cancer Epidemiol Biomarkers Prev. 2013 Mar;22(3):461-6 - PubMed
  84. Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96 - PubMed
  85. Gene. 2012 Oct 1;507(1):95-8 - PubMed
  86. Cancer Res. 2010 Apr 1;70(7):2789-98 - PubMed
  87. Nat Immunol. 2004 Nov;5(11):1134-42 - PubMed
  88. Am J Cancer Res. 2012;2(3):298-308 - PubMed
  89. Cancer Res. 2010 Jan 1;70(1):36-45 - PubMed
  90. J Immunol. 1992 May 15;148(10):3302-12 - PubMed
  91. Clin Cancer Res. 2006 Dec 1;12(23):7194-201 - PubMed
  92. Anticancer Res. 2008 May-Jun;28(3A):1525-9 - PubMed
  93. Nat Rev Genet. 2008 Feb;9(2):102-14 - PubMed
  94. J Clin Oncol. 2004 Jul 1;22(13):2594-601 - PubMed
  95. PLoS One. 2011;6(7):e22509 - PubMed
  96. Gastroenterology. 2010 Jun;138(6):2101-2114.e5 - PubMed
  97. PLoS One. 2012;7(12):e49823 - PubMed
  98. PLoS One. 2010 May 19;5(5):e10714 - PubMed
  99. Cell. 2003 Dec 26;115(7):787-98 - PubMed
  100. Endocr Relat Cancer. 2008 Sep;15(3):657-64 - PubMed
  101. Pharmacol Ther. 2013 Jan;137(1):55-63 - PubMed
  102. Cancer Res. 2004 Sep 1;64(17):6214-24 - PubMed
  103. Oncogene. 2013 Jan 10;32(2):242-50 - PubMed
  104. Mol Cell. 2010 Oct 8;40(1):22-33 - PubMed
  105. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13561-2 - PubMed
  106. Cancer Res. 2008 Oct 15;68(20):8535-40 - PubMed
  107. Mol Cell. 2008 Feb 29;29(4):517-24 - PubMed
  108. J Clin Invest. 2008 Jul;118(7):2600-8 - PubMed
  109. Mutagenesis. 2013 Jan;28(1):49-55 - PubMed
  110. Int J Oncol. 2011 Apr;38(4):1153-61 - PubMed
  111. PLoS One. 2013 May 28;8(5):e64331 - PubMed
  112. Cell Death Dis. 2012 Nov 15;3:e423 - PubMed
  113. Biochemistry. 1996 Jun 18;35(24):8035-44 - PubMed
  114. Cell. 1982 Nov;31(1):11-24 - PubMed
  115. Nat Rev Cancer. 2010 Jun;10(6):389-402 - PubMed
  116. Int J Colorectal Dis. 2004 Jan;19(1):23-42 - PubMed
  117. Lung Cancer. 2010 Jul;69(1):51-3 - PubMed
  118. Cancer Res. 2010 Dec 1;70(23):9765-76 - PubMed
  119. J Clin Oncol. 2008 Jan 20;26(3):374-9 - PubMed
  120. Histochem Cell Biol. 2008 Jun;129(6):705-33 - PubMed
  121. Breast Cancer Res Treat. 2008 Jul;110(1):1-7 - PubMed
  122. Pharmacogenomics. 2009 Mar;10(3):399-416 - PubMed
  123. J Gastroenterol. 2009;44 Suppl 19:96-101 - PubMed
  124. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13513-8 - PubMed
  125. Clin Cancer Res. 2013 Nov 1;19(21):6044-56 - PubMed
  126. Carcinogenesis. 2010 Dec;31(12):2118-23 - PubMed
  127. World J Gastroenterol. 2012 Jan 28;18(4):383-7 - PubMed
  128. Blood. 1994 Dec 1;84(11):3637-47 - PubMed
  129. Nat Rev Cancer. 2005 Nov;5(11):845-56 - PubMed
  130. Nat Genet. 2006 Jul;38(7):813-8 - PubMed
  131. J Natl Cancer Inst. 2002 May 1;94(9):681-90 - PubMed
  132. Mol Cancer Res. 2012 Jan;10(1):86-95 - PubMed
  133. Mol Cell. 2007 Aug 17;27(4):636-46 - PubMed
  134. Cancer Res. 2011 Aug 1;71(15):5175-81 - PubMed
  135. Int J Cancer. 2012 Sep 15;131(6):1318-22 - PubMed
  136. Carcinogenesis. 2013 Mar;34(3):689-93 - PubMed
  137. Int J Cancer. 2010 Dec 1;127(11):2520-9 - PubMed
  138. Clin Cancer Res. 2011 Jun 1;17(11):3742-50 - PubMed
  139. Neoplasia. 2011 Oct;13(10):961-70 - PubMed
  140. Cancer Res. 2012 Jul 1;72(13):3217-27 - PubMed
  141. Front Biosci (Landmark Ed). 2011 Jan 01;16:1144-56 - PubMed
  142. J Virol. 2012 Feb;86(3):1544-54 - PubMed
  143. Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1869-80 - PubMed
  144. EMBO J. 1990 May;9(5):1495-502 - PubMed
  145. Ann N Y Acad Sci. 1995 Sep 30;768:91-100 - PubMed
  146. Cell Mol Life Sci. 2009 Mar;66(5):788-99 - PubMed
  147. BMC Cancer. 2011 Feb 22;11:80 - PubMed
  148. Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):527-33 - PubMed
  149. J Natl Cancer Inst. 2007 Apr 4;99(7):558-68 - PubMed
  150. J Natl Cancer Inst. 1999 Jan 20;91(2):176-81 - PubMed

Publication Types