Display options
Cite
Kafshgari MH, Cavallaro A, Delalat B, et al. Nitric oxide-releasing porous silicon nanoparticles. Nanoscale Res Lett. 2014;9(1):333doi: 10.1186/1556-276X-9-333.
Kafshgari, M. H., Cavallaro, A., Delalat, B., Harding, F. J., McInnes, S. J., Mäkilä, E., Salonen, J., Vasilev, K., & Voelcker, N. H. (2014). Nitric oxide-releasing porous silicon nanoparticles. Nanoscale research letters, 9(1), 333. https://doi.org/10.1186/1556-276X-9-333
Kafshgari, Morteza Hasanzadeh, et al. "Nitric oxide-releasing porous silicon nanoparticles." Nanoscale research letters vol. 9,1 (2014): 333. doi: https://doi.org/10.1186/1556-276X-9-333
Kafshgari MH, Cavallaro A, Delalat B, Harding FJ, McInnes SJ, Mäkilä E, Salonen J, Vasilev K, Voelcker NH. Nitric oxide-releasing porous silicon nanoparticles. Nanoscale Res Lett. 2014 Jul 04;9(1):333. doi: 10.1186/1556-276X-9-333. eCollection 2014. PMID: 25114633; PMCID: PMC4109794.
Copy Download .nbib Format: NLM
Share it on

Nanoscale Res Lett. 2014 Jul 04;9(1):333. doi: 10.1186/1556-276X-9-333. eCollection 2014.

Nitric oxide-releasing porous silicon nanoparticles.

Nanoscale research letters

Morteza Hasanzadeh Kafshgari, Alex Cavallaro, Bahman Delalat, Frances J Harding, Steven Jp McInnes, Ermei Mäkilä, Jarno Salonen, Krasimir Vasilev, Nicolas H Voelcker

Affiliations

  1. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, GPO Box 2471 Adelaide, SA 5001, Australia.
  2. Department of Physics and Astronomy, University of Turku, Turku FI-20014, Finland.

PMID: 25114633 PMCID: PMC4109794 DOI: 10.1186/1556-276X-9-333

Abstract

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

Keywords: Antibacterial; Nitric oxide; Porous silicon nanoparticles

References

  1. Adv Healthc Mater. 2013 Oct;2(10):1351-60 - PubMed
  2. J Pharm Sci. 2008 Feb;97(2):632-53 - PubMed
  3. Lancet. 2001 Jul 14;358(9276):135-8 - PubMed
  4. Nitric Oxide. 2008 Aug;19(1):12-20 - PubMed
  5. Anal Biochem. 2002 Aug 1;307(1):167-72 - PubMed
  6. Metabolism. 2002 Oct;51(10):1269-73 - PubMed
  7. Expert Opin Drug Deliv. 2009 Oct;6(10):1113-22 - PubMed
  8. Clin Infect Dis. 2013 Jun;56(11):1614-20 - PubMed
  9. J Am Acad Dermatol. 2008 Feb;58(2):185-206 - PubMed
  10. Biomaterials. 2005 Mar;26(8):917-24 - PubMed
  11. Dermatol Online J. 2013 Feb 15;19(2):7 - PubMed
  12. Future Med Chem. 2009 Sep;1(6):1051-74 - PubMed
  13. Dermatol Online J. 2013 Feb 15;19(2):5 - PubMed
  14. Anal Chem. 1998 Jul 1;70(13):2446-53 - PubMed
  15. ACS Nano. 2011 Sep 27;5(9):7235-44 - PubMed
  16. J Biol Chem. 2006 Nov 24;281(47):36021-8 - PubMed
  17. Am J Surg. 2002 Apr;183(4):406-12 - PubMed
  18. Environ Sci Technol. 2007 Mar 15;41(6):2064-8 - PubMed
  19. Arch Med Res. 2005 Sep-Oct;36(5):464-7 - PubMed
  20. J Invest Dermatol. 2009 Oct;129(10):2463-9 - PubMed
  21. Adv Drug Deliv Rev. 2008 Aug 17;60(11):1266-77 - PubMed
  22. ACS Nano. 2009 Feb 24;3(2):279-90 - PubMed
  23. Ann Biomed Eng. 2005 Feb;33(2):214-22 - PubMed
  24. Acta Biomater. 2010 Jul;6(7):2721-31 - PubMed
  25. Microbiol Mol Biol Rev. 1997 Dec;61(4):533-616 - PubMed
  26. ACS Nano. 2008 Feb;2(2):235-46 - PubMed
  27. Trends Biotechnol. 2012 Oct;30(10):499-511 - PubMed
  28. ACS Nano. 2010 Jun 22;4(6):3023-32 - PubMed
  29. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10480-4 - PubMed
  30. Biomaterials. 2009 May;30(14):2782-9 - PubMed
  31. Nitric Oxide. 2006 Feb;14(1):21-9 - PubMed
  32. Biomaterials. 2011 Apr;32(10):2625-33 - PubMed
  33. Nanoscale Res Lett. 2012 Jun 19;7:311 - PubMed
  34. Int Wound J. 2015 Apr;12(2):169-72 - PubMed
  35. Carbohydr Res. 2004 Nov 15;339(16):2693-700 - PubMed
  36. J Clin Microbiol. 1998 Jun;36(6):1683-7 - PubMed
  37. World J Surg. 2004 Mar;28(3):301-6 - PubMed
  38. Biotechnol Adv. 2009 Jan-Feb;27(1):76-83 - PubMed

Publication Types