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Yu Z, Yu M, Zhang Z, et al. Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear. Nanoscale Res Lett. 2014;9(1):343doi: 10.1186/1556-276X-9-343.
Yu, Z., Yu, M., Zhang, Z., Hong, G., & Xiong, Q. (2014). Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear. Nanoscale research letters, 9(1), 343. https://doi.org/10.1186/1556-276X-9-343
Yu, Zhan, et al. "Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear." Nanoscale research letters vol. 9,1 (2014): 343. doi: https://doi.org/10.1186/1556-276X-9-343
Yu Z, Yu M, Zhang Z, Hong G, Xiong Q. Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear. Nanoscale Res Lett. 2014 Jul 09;9(1):343. doi: 10.1186/1556-276X-9-343. eCollection 2014. PMID: 25114637; PMCID: PMC4106659.
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Nanoscale Res Lett. 2014 Jul 09;9(1):343. doi: 10.1186/1556-276X-9-343. eCollection 2014.

Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear.

Nanoscale research letters

Zhan Yu, Min Yu, Zhibao Zhang, Ge Hong, Qingqing Xiong

Affiliations

  1. Department of ENT, The Second Artillery General Hospital of Chinese People's Liberation Army, 16 Xinjiekou Outer Avenue, Beijing 100088, People's Republic of China.
  2. Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, 92 Beier Road, Shenyang 110001, People's Republic of China.
  3. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, People's Republic of China.

PMID: 25114637 PMCID: PMC4106659 DOI: 10.1186/1556-276X-9-343

Abstract

Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles could adhere on and penetrate through the round window membrane of guinea pigs. The nanoparticles were analyzed as drug carriers to investigate the loading capacity and release behaviors. Rhodamine B was used as a model drug in this paper. Rhodamine B-loaded nanoparticles showed a controlled release profile and could be deposited on the osseous spiral lamina. We considered that the bovine serum albumin nanoparticles may have potential applications in the field of local drug delivery in the treatment of inner ear disorders.

Keywords: Bovine serum albumin; Controlled release; Drug delivery; Inner ear; Nanoparticle; Round window membrane

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