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Parmar PG, Marsh JA, Rob Taal H, et al. Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth. J Dev Orig Health Dis. 2013;4(2):157-69doi: 10.1017/S2040174412000633.
Parmar, P. G., Marsh, J. A., Rob Taal, H., Kowgier, M., Uitterlinden, A. G., Rivadeneira, F., Briollais, L., Newnham, J. P., Hofman, A., Lye, S. J., Steegers, E. A., van Duijn, C. M., Palmer, L. J., Jaddoe, V. W., & Pennell, C. E. (2013). Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth. Journal of developmental origins of health and disease, 4(2), 157-69. https://doi.org/10.1017/S2040174412000633
Parmar, P G, et al. "Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth." Journal of developmental origins of health and disease vol. 4,2 (2013): 157-69. doi: https://doi.org/10.1017/S2040174412000633
Parmar PG, Marsh JA, Rob Taal H, Kowgier M, Uitterlinden AG, Rivadeneira F, Briollais L, Newnham JP, Hofman A, Lye SJ, Steegers EA, van Duijn CM, Palmer LJ, Jaddoe VW, Pennell CE. Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth. J Dev Orig Health Dis. 2013 Apr;4(2):157-69. doi: 10.1017/S2040174412000633. PMID: 25054682.
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J Dev Orig Health Dis. 2013 Apr;4(2):157-69. doi: 10.1017/S2040174412000633.

Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth.

Journal of developmental origins of health and disease

P G Parmar, J A Marsh, H Rob Taal, M Kowgier, A G Uitterlinden, F Rivadeneira, L Briollais, J P Newnham, A Hofman, S J Lye, E A P Steegers, C M van Duijn, L J Palmer, V W V Jaddoe, C E Pennell

Affiliations

  1. 1 School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.
  2. 2 The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
  3. 5 Samuel Lunenfeld Research Institute, University of Toronto, Ontario, Canada.
  4. 3 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  5. 8 Department of Obstetrics Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands.

PMID: 25054682 DOI: 10.1017/S2040174412000633

Abstract

Two pregnancy cohorts were used to investigate the association between single-nucleotide polymorphisms (SNPs) in genes within the insulin-like growth factor (IGF)-axis and antenatal and postnatal growth from birth to adolescence. Longitudinal analyses were conducted in the Raine pregnancy cohort (n = 1162) using repeated measures of fetal head circumference (HC), abdominal circumference (AC) and femur length (FL) from 18 to 38 weeks gestation and eight measures of postnatal height and weight (1-17 years). Replications of significant associations up to birth were undertaken in the Generation R Study (n = 2642). Of the SNPs within the IGF-axis genes, 40% (n = 58) were associated with measures of antenatal growth (P ⩽ 0.05). The majority of these SNPs were in receptors; IGF-1R (23%; n = 34) and IGF-2R (13%; n = 9). Fifteen SNPs were associated with antenatal growth (either AC or HC or FL) in Raine (P ⩽ 0.005): five of which remained significant after adjusting for multiple testing. Four of these replicated in Generation R. Associations were identified between 38% (n = 55) of the IGF-axis SNPs and postnatal height and weight; 21% in IGF-1R (n = 31) and 9% in IGF-2R (n = 13). Twenty-six SNPs were significantly associated with both antenatal and postnatal growth; 17 with discordant effects and nine with concordant effects. Genetic variants in the IGF-axis appear to play a significant role in antenatal and postnatal growth. Further replication and new analytic methods are required in order to better understand this key metabolic pathway integrating biologic knowledge about the interaction between IGF-axis components.

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