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Betts A, Kaltz O, Hochberg ME. Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proc Natl Acad Sci U S A. 2014;111(30):11109-14doi: 10.1073/pnas.1406763111.
Betts, A., Kaltz, O., & Hochberg, M. E. (2014). Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proceedings of the National Academy of Sciences of the United States of America, 111(30), 11109-14. https://doi.org/10.1073/pnas.1406763111
Betts, Alex, et al. "Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages." Proceedings of the National Academy of Sciences of the United States of America vol. 111,30 (2014): 11109-14. doi: https://doi.org/10.1073/pnas.1406763111
Betts A, Kaltz O, Hochberg ME. Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11109-14. doi: 10.1073/pnas.1406763111. Epub 2014 Jul 14. PMID: 25024215; PMCID: PMC4121802.
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Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11109-14. doi: 10.1073/pnas.1406763111. Epub 2014 Jul 14.

Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages.

Proceedings of the National Academy of Sciences of the United States of America

Alex Betts, Oliver Kaltz, Michael E Hochberg

Affiliations

  1. Institut des Sciences de l'Evolution, Université Montpellier II, Unité Mixte de Recherche 5554, 34095 Montpellier Cedex 05, France;Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom;
  2. Institut des Sciences de l'Evolution, Université Montpellier II, Unité Mixte de Recherche 5554, 34095 Montpellier Cedex 05, France;
  3. Institut des Sciences de l'Evolution, Université Montpellier II, Unité Mixte de Recherche 5554, 34095 Montpellier Cedex 05, France;Santa Fe Institute, Santa Fe, NM 87501; andWissenschaftskolleg zu Berlin, 14193 Berlin, Germany [email protected].

PMID: 25024215 PMCID: PMC4121802 DOI: 10.1073/pnas.1406763111

Abstract

Many antagonistic interactions between hosts and their parasites result in coevolution. Although coevolution can drive diversity and specificity within species, it is not known whether coevolutionary dynamics differ among functionally similar species. We present evidence of coevolution within simple communities of Pseudomonas aeruginosa PAO1 and a panel of bacteriophages. Pathogen identity affected coevolutionary dynamics. For five of six phages tested, time-shift assays revealed temporal peaks in bacterial resistance and phage infectivity, consistent with frequency-dependent selection (Red Queen dynamics). Two of the six phages also imposed additional directional selection, resulting in strongly increased resistance ranges over the entire length of the experiment (ca. 60 generations). Cross-resistance to these two phages was very high, independent of the coevolutionary history of the bacteria. We suggest that coevolutionary dynamics are associated with the nature of the receptor used by the phage for infection. Our results shed light on the coevolutionary process in simple communities and have practical application in the control of bacterial pathogens through the evolutionary training of phages, increasing their virulence and efficacy as therapeutics or disinfectants.

Keywords: arms race; fluctuating selection; nosocomial pathogen; phage therapy; type IV pili

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