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Forsberg L, Wide K. Long-term consequences after exposure to antiepileptic drugs in utero. Ther Adv Drug Saf. 2011;2(5):227-34doi: 10.1177/2042098611419003.
Forsberg, L., & Wide, K. (2011). Long-term consequences after exposure to antiepileptic drugs in utero. Therapeutic advances in drug safety, 2(5), 227-34. https://doi.org/10.1177/2042098611419003
Forsberg, Lisa, and Wide, Katarina. "Long-term consequences after exposure to antiepileptic drugs in utero." Therapeutic advances in drug safety vol. 2,5 (2011): 227-34. doi: https://doi.org/10.1177/2042098611419003
Forsberg L, Wide K. Long-term consequences after exposure to antiepileptic drugs in utero. Ther Adv Drug Saf. 2011 Oct;2(5):227-34. doi: 10.1177/2042098611419003. PMID: 25083215; PMCID: PMC4110809.
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Ther Adv Drug Saf. 2011 Oct;2(5):227-34. doi: 10.1177/2042098611419003.

Long-term consequences after exposure to antiepileptic drugs in utero.

Therapeutic advances in drug safety

Lisa Forsberg, Katarina Wide

Affiliations

  1. Astrid Lindgren Children's Hospital at Karolinska University Hospital Huddinge and Department of Clinical Science, Intervention and Technique (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

PMID: 25083215 PMCID: PMC4110809 DOI: 10.1177/2042098611419003

Abstract

Most pregnant women with epilepsy need pharmacological treatment during pregnancy. Children exposed to antiepileptic drugs have an increased risk of being born with major malformations. Some antiepileptic drugs seem to have negative effects on psychomotor or cognitive development in children exposed during foetal life. Neither carbamazepine nor lamotrigine in monotherapy seem to affect the cognition of exposed children. Several studies have shown negative effects on the long-term neurodevelopment of children prenatally exposed to valproic acid or polytherapy (two or more antiepileptic drugs during pregnancy). For most of the newer antiepileptic drugs there are insufficient data regarding long-term outcome.

Keywords: anticonvulsants; child development; cognitive; epilepsy; intelligence; neurodevelopment; pregnancy

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