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Palumbo A, Palladino C. Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance. Ther Adv Drug Saf. 2012;3(5):255-66doi: 10.1177/2042098612452291.
Palumbo, A., & Palladino, C. (2012). Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance. Therapeutic advances in drug safety, 3(5), 255-66. https://doi.org/10.1177/2042098612452291
Palumbo, Antonio, and Palladino, Carmela. "Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance." Therapeutic advances in drug safety vol. 3,5 (2012): 255-66. doi: https://doi.org/10.1177/2042098612452291
Palumbo A, Palladino C. Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance. Ther Adv Drug Saf. 2012 Oct;3(5):255-66. doi: 10.1177/2042098612452291. PMID: 25083240; PMCID: PMC4110867.
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Ther Adv Drug Saf. 2012 Oct;3(5):255-66. doi: 10.1177/2042098612452291.

Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance.

Therapeutic advances in drug safety

Antonio Palumbo, Carmela Palladino

Affiliations

  1. Myeloma Unit, Division of Hematology, University of Torino, AOU San Giovanni Battista, Torino, Italy.

PMID: 25083240 PMCID: PMC4110867 DOI: 10.1177/2042098612452291

Abstract

Oral immunomodulatory drugs (IMiDs), namely thalidomide, lenalidomide and pomalidomide, interfere with several pathways important for disease progression. Today they play a crucial role in the treatment of multiple myeloma patients, and have considerably improved myeloma outcomes. These agents, and thalidomide in particular, are associated with higher rates of thromboembolic events, both venous and arterial. Individual risk factors for thromboembolic events include advanced age, previous history of thromboembolism, an indwelling central venous catheter, comorbid conditions (e.g. infections, diabetes, cardiac disease, obesity), current or recent immobilization, recent surgery and inherited thrombophilic abnormalities. Cancer therapy and cancer itself also increase the risk of thromboembolic events. The aim of this review is to help clinicians to define the risk of thrombotic events in patients treated with thalidomide and thus to provide practical recommendations to manage thromboprophylaxis in these patients.

Keywords: aspirin; heparin; multiple myeloma; novel agents; thalidomide; thromboprophylaxis; venous thromboembolism; warfarin

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