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Telakis E, Tsironi E, Papatheodorou K, et al. Debilitating chronic diarrhea caused by generalized gastrointestinal cytomegalovirus infection in an immunocompetent adult. Case Rep Gastrointest Med. 2014;2014:260120doi: 10.1155/2014/260120.
Telakis, E., Tsironi, E., Papatheodorou, K., & Nikolakis, D. (2014). Debilitating chronic diarrhea caused by generalized gastrointestinal cytomegalovirus infection in an immunocompetent adult. Case reports in gastrointestinal medicine, 2014260120. https://doi.org/10.1155/2014/260120
Telakis, Emmanouil, et al. "Debilitating chronic diarrhea caused by generalized gastrointestinal cytomegalovirus infection in an immunocompetent adult." Case reports in gastrointestinal medicine vol. 2014 (2014): 260120. doi: https://doi.org/10.1155/2014/260120
Telakis E, Tsironi E, Papatheodorou K, Nikolakis D. Debilitating chronic diarrhea caused by generalized gastrointestinal cytomegalovirus infection in an immunocompetent adult. Case Rep Gastrointest Med. 2014;2014:260120. doi: 10.1155/2014/260120. Epub 2014 Jun 12. PMID: 25024853; PMCID: PMC4082948.
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Case Rep Gastrointest Med. 2014;2014:260120. doi: 10.1155/2014/260120. Epub 2014 Jun 12.

Debilitating chronic diarrhea caused by generalized gastrointestinal cytomegalovirus infection in an immunocompetent adult.

Case reports in gastrointestinal medicine

Emmanouil Telakis, Eftychia Tsironi, Konstantinos Papatheodorou, Dimitrios Nikolakis

Affiliations

  1. Department of Gastrointestinal Endoscopy, Bioclinic of Piraeus, 34 Filellinon Street, 18536 Piraeus, Greece.
  2. Department of Gastroenterology, "Metaxa" Memorial Cancer Hospital of Piraeus, 51 Mpotasi Street, 18537 Piraeus, Greece.

PMID: 25024853 PMCID: PMC4082948 DOI: 10.1155/2014/260120

Abstract

Gastrointestinal cytomegalovirus (CMV) infection is a common opportunistic infection in immunocompromised patients, especially patients with acquired immunodeficiency syndrome and transplant recipients. In contrast, CMV infection of the gastrointestinal tract is rare in immunocompetent individuals. We report a case of severe, protracted, and debilitating diarrhea caused by generalized CMV infection of the gastrointestinal tract in an elderly woman with no apparent immunosuppression. An extensive diagnostic investigation demonstrated CMV-associated disease affecting both the upper and lower gastrointestinal tracts (esophagus, small intestine, and colon). Such extensive simultaneous involvement of the alimentary tract in an immunocompetent patient is rare and presents a diagnostic and therapeutic challenge. The diagnosis was based on a combination of endoscopic, histopathological, serological, and polymerase chain reaction analysis findings and our patient was successfully treated with intravenous ganciclovir. Our case demonstrates that gastrointestinal CMV infection should be considered in the differential diagnosis of severe chronic diarrhea in immunocompetent patients and that antiviral treatment may be justified in this setting.

References

  1. Curr Gastroenterol Rep. 2012 Aug;14(4):334-42 - PubMed
  2. Dig Dis Sci. 2005 Apr;50(4):609-16 - PubMed
  3. Am J Gastroenterol. 2006 Dec;101(12):2857-65 - PubMed
  4. Mt Sinai J Med. 1999 Mar;66(2):113-24 - PubMed
  5. J Clin Gastroenterol. 1996 Jan;22(1):41-4 - PubMed
  6. Virol J. 2008 Mar 27;5:47 - PubMed
  7. Dis Colon Rectum. 2001 Nov;44(11):1716-20 - PubMed
  8. Am J Gastroenterol. 1996 Jan;91(1):168-9 - PubMed
  9. Ann Intern Med. 1993 Nov 1;119(9):924-35 - PubMed
  10. Am Fam Physician. 2003 Feb 1;67(3):519-24 - PubMed
  11. Aliment Pharmacol Ther. 2008 Apr 1;27(7):578-87 - PubMed
  12. Scand J Infect Dis. 1998;30(6):559-64 - PubMed
  13. Dig Dis Sci. 1996 Jun;41(6):1183-93 - PubMed

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