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Schuessler A, Walker DG, Khanna R. Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment. Oncoimmunology. 2014;3:e29381doi: 10.4161/onci.29381.
Schuessler, A., Walker, D. G., & Khanna, R. (2014). Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment. Oncoimmunology, 3e29381. https://doi.org/10.4161/onci.29381
Schuessler, Andrea, et al. "Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment." Oncoimmunology vol. 3 (2014): e29381. doi: https://doi.org/10.4161/onci.29381
Schuessler A, Walker DG, Khanna R. Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment. Oncoimmunology. 2014 Jun 25;3:e29381. doi: 10.4161/onci.29381. eCollection 2014. PMID: 25083342; PMCID: PMC4108464.
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Oncoimmunology. 2014 Jun 25;3:e29381. doi: 10.4161/onci.29381. eCollection 2014.

Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment.

Oncoimmunology

Andrea Schuessler, David G Walker, Rajiv Khanna

Affiliations

  1. QIMR Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory; Department of Immunology; QIMR Berghofer Medical Research Institute; Brisbane, QLD Australia.
  2. Newro Foundation; The Wesley Hospital; Brisbane, QLD Australia.

PMID: 25083342 PMCID: PMC4108464 DOI: 10.4161/onci.29381

Abstract

Glioblastoma multiforme (GBM) has a very poor prognosis, despite multimodal therapy including surgery, radiation and chemotherapy. A novel adoptive immunotherapy that exploits the presence of cytomegalovirus antigens in malignant brain cancer cells has been shown to be safe and elicit potential clinical benefit for the treatment of recurrent GBM.

Keywords: adoptive immunotherapy; clinical trial; cytomegalovirus; cytotoxic T cells; recurrent glioblastoma multiforme

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