Display options
Cite
Weinberg BD, Newell KL, Wang F. A case of a Beta-human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma. J Neurol Surg Rep. 2014;75(1):e103-7doi: 10.1055/s-0034-1373667.
Weinberg, B. D., Newell, K. L., & Wang, F. (2014). A case of a Beta-human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma. Journal of neurological surgery reports, 75(1), e103-7. https://doi.org/10.1055/s-0034-1373667
Weinberg, Benjamin D, et al. "A case of a Beta-human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma." Journal of neurological surgery reports vol. 75,1 (2014): e103-7. doi: https://doi.org/10.1055/s-0034-1373667
Weinberg BD, Newell KL, Wang F. A case of a Beta-human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma. J Neurol Surg Rep. 2014 Aug;75(1):e103-7. doi: 10.1055/s-0034-1373667. Epub 2014 May 02. PMID: 25083366; PMCID: PMC4110143.
Copy Download .nbib Format: NLM
Share it on

J Neurol Surg Rep. 2014 Aug;75(1):e103-7. doi: 10.1055/s-0034-1373667. Epub 2014 May 02.

A case of a Beta-human chorionic gonadotropin secreting sinonasal teratocarcinosarcoma.

Journal of neurological surgery reports

Benjamin D Weinberg, Kathy L Newell, Fen Wang

Affiliations

  1. Department of Radiation Oncology, Wayne State University, Detroit, Michigan, United States.
  2. Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas, United States.
  3. Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, United States.

PMID: 25083366 PMCID: PMC4110143 DOI: 10.1055/s-0034-1373667

Abstract

Background and Importance Sinonasal teratocarcinosarcoma (SNTCS) is an unusual and aggressive neoplasm characterized by the combination of teratoma and carcinosarcoma features that is often misdiagnosed based on a biopsy sample. Approximately 60 cases have been reported in the English literature, but none have been associated with serum tumor markers. We report a case of SNTCS with elevation of serum β-human chorionic gonadotropin (hCG) level. Clinical Presentation The patient was a 22-year-old pregnant woman at diagnosis, and her β-hCG level was appropriately elevated. Her initial treatment was a surgical resection followed by radiation therapy (RT). Two years later, the patient had a pregnancy work-up after a sexual assault. Her serum β-hCG was elevated, but a nongravid uterus was seen on ultrasound. Magnetic resonance imaging (MRI) of the head revealed an intracranial tumor recurrence in the right frontal lobe. During salvage RT, β-hCG decreased rapidly to normal levels, with a complete tumor response on MRI. Retrospective examination of the initial surgical specimen showed expression of β-hCG associated with the anaplastic mesenchymal component. Conclusion This is the first reported case of a β-hCG secreting SNTCS. The source of β-hCG production was traced to a neoplastic smooth muscle component of the tumor.

Keywords: gonadotropin; intracranial; serum; teratocarcinosarcoma; β-hCG

References

  1. Clin Neuropathol. 2000 Mar-Apr;19(2):63-9 - PubMed
  2. Hum Pathol. 1998 Jul;29(7):718-22 - PubMed
  3. Ann Diagn Pathol. 2008 Dec;12(6):415-25 - PubMed
  4. Cancer. 1984 May 15;53(10):2140-54 - PubMed
  5. Sarcoma. 2000;4(4):179-81 - PubMed
  6. Int J Gynecol Pathol. 2006 Jul;25(3):257-61 - PubMed
  7. Head Neck Pathol. 2009 Mar;3(1):31-6 - PubMed
  8. J Neurosurg Pediatr. 2012 Aug;10(2):121-5 - PubMed
  9. Otolaryngol Head Neck Surg. 1995 Mar;112(3):496-500 - PubMed

Publication Types