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Billingsley JT, Wiet RM, Petruzzelli GJ, et al. A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 2014;75(1):e175-9doi: 10.1055/s-0034-1378153.
Billingsley, J. T., Wiet, R. M., Petruzzelli, G. J., & Byrne, R. (2014). A locally invasive giant cell tumor of the skull base: case report. Journal of neurological surgery reports, 75(1), e175-9. https://doi.org/10.1055/s-0034-1378153
Billingsley, J T, et al. "A locally invasive giant cell tumor of the skull base: case report." Journal of neurological surgery reports vol. 75,1 (2014): e175-9. doi: https://doi.org/10.1055/s-0034-1378153
Billingsley JT, Wiet RM, Petruzzelli GJ, Byrne R. A locally invasive giant cell tumor of the skull base: case report. J Neurol Surg Rep. 2014 Aug;75(1):e175-9. doi: 10.1055/s-0034-1378153. Epub 2014 Jun 24. PMID: 25083380; PMCID: PMC4110128.
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J Neurol Surg Rep. 2014 Aug;75(1):e175-9. doi: 10.1055/s-0034-1378153. Epub 2014 Jun 24.

A locally invasive giant cell tumor of the skull base: case report.

Journal of neurological surgery reports

J T Billingsley, R M Wiet, G J Petruzzelli, R Byrne

Affiliations

  1. Department of Neurosurgery, Rush University, Chicago, Illinois, United States.
  2. Department of Otolaryngology - Head and Neck Surgery, Rush University, Chicago, Illinois, United States.
  3. Department of Otolaryngology, Rush University Medical Center, Chicago, Illinois, United States.

PMID: 25083380 PMCID: PMC4110128 DOI: 10.1055/s-0034-1378153

Abstract

Giant cell tumors (GCTs) are rare, usually affecting the epiphyses in long bones of the extremities. They seldom occur in the skull, where they preferentially affect the sphenoid and temporal bones. Considered to be benign, locally aggressive lesions, they may cause cranial nerve deficits by compression but infrequently invade the dura and parenchyma of the brain. Several case reports with follow-up describe gross total resection of skull base GCT to be curative. Anything short of total resection usually results in recurrence within 4 years. Radiation therapy, although controversial, is reserved for lesions that cannot be completely resected. Some argue, however, against the use of radiation because there are reported cases of malignant transformation. Here we describe the case of a large GCT that was invasive to the dura, temporal lobe, as well as the third division of the trigeminal nerve, and to date gross total resection has been curative of this lesion. The patient has not undergone radiation therapy.

Keywords: GCT; epiphyses; extremities; giant cell tumors; radiotherapy; skull base tumor; temporal bone

References

  1. Am J Pathol. 1996 Feb;148(2):611-22 - PubMed
  2. J Cancer Res Clin Oncol. 2001 Aug;127(8):467-74 - PubMed
  3. Neuroradiology. 1999 Apr;41(4):305-7 - PubMed
  4. Cancer. 1970 May;25(5):1061-70 - PubMed
  5. Skull Base. 2009 Jul;19(4):291-301 - PubMed
  6. Radiology. 1986 Nov;161(2):537-40 - PubMed
  7. AJR Am J Roentgenol. 1985 May;144(5):955-60 - PubMed
  8. J Neurol Neurosurg Psychiatry. 1977 Aug;40(8):790-4 - PubMed
  9. Cancer. 1992 Sep 1;70(5):1124-32 - PubMed
  10. Laryngoscope. 1974 Jul;84(7):1181-7 - PubMed
  11. J Bone Joint Surg Am. 1970 Jun;52(4):619-64 - PubMed
  12. Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):689-94 - PubMed
  13. Skeletal Radiol. 1997 Apr;26(4):246-55 - PubMed
  14. J Neurosurg. 1983 Aug;59(2):322-7 - PubMed
  15. Cancer. 1980 Oct 1;46(7):1641-9 - PubMed
  16. Surg Neurol. 2004 Mar;61(3):274-7 - PubMed
  17. J Neurosurg. 1987 Jun;66(6):924-8 - PubMed
  18. J Anat. 2001 Jul-Aug;199(Pt 1-2):143-51 - PubMed

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