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Sakai N, Ito-Yamashita T, Takahashi G, et al. Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. J Neurol Surg Rep. 2014;75(1):e62-6doi: 10.1055/s-0033-1363505.
Sakai, N., Ito-Yamashita, T., Takahashi, G., Baba, S., Koizumi, S., Yamasaki, T., Tokuyama, T., & Namba, H. (2014). Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. Journal of neurological surgery reports, 75(1), e62-6. https://doi.org/10.1055/s-0033-1363505
Sakai, Naoto, et al. "Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report." Journal of neurological surgery reports vol. 75,1 (2014): e62-6. doi: https://doi.org/10.1055/s-0033-1363505
Sakai N, Ito-Yamashita T, Takahashi G, Baba S, Koizumi S, Yamasaki T, Tokuyama T, Namba H. Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. J Neurol Surg Rep. 2014 Aug;75(1):e62-6. doi: 10.1055/s-0033-1363505. Epub 2014 Jan 16. PMID: 25083392; PMCID: PMC4110151.
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J Neurol Surg Rep. 2014 Aug;75(1):e62-6. doi: 10.1055/s-0033-1363505. Epub 2014 Jan 16.

Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report.

Journal of neurological surgery reports

Naoto Sakai, Tae Ito-Yamashita, Goro Takahashi, Satoshi Baba, Shinichiro Koizumi, Tomohiro Yamasaki, Tsutomu Tokuyama, Hiroki Namba

Affiliations

  1. Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan.
  2. Department of Otolaryngology, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan.
  3. Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Handayama, Higashiku, Hamamatsu, Japan.

PMID: 25083392 PMCID: PMC4110151 DOI: 10.1055/s-0033-1363505

Abstract

Primary neurolymphomatosis is an extremely rare tumor. We report the case of a 74-year-old patient presenting with dysphagia and hoarseness. Initial contrast-enhanced computed tomography of the head, neck, and chest did not reveal any lesions. His symptoms improved with short-term administration of prednisone but recurred and deteriorated. Magnetic resonance (MR) imaging revealed a tumor along the ninth and tenth cranial nerves across the jugular foramen. Fluorine-18 fluorodeoxyglucose positron emission tomography indicated this was a primary tumor. Repeated MR imaging after 2 months revealed considerable tumor enlargement. A left suboccipital craniotomy was performed to remove the tumor that infiltrated the ninth and tenth cranial nerves. The histopathologic diagnosis was diffuse large B-cell lymphoma. Although focal radiation therapy was administered to ensure complete eradication of the tumor, the patient died of aspiration pneumonia with systemic metastasis. To our knowledge, this is the first reported case of primary neurolymphomatosis in the lower cranial nerves.

Keywords: cranial nerve; large B-cell lymphoma; lower cranial nerves; malignant lymphoma; neurolymphomatosis

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