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Wilkerson BA, Argraves KM. The role of sphingosine-1-phosphate in endothelial barrier function. Biochim Biophys Acta. 2014;1841(10):1403-1412doi: 10.1016/j.bbalip.2014.06.012.
Wilkerson, B. A., & Argraves, K. M. (2014). The role of sphingosine-1-phosphate in endothelial barrier function. Biochimica et biophysica acta, 1841(10), 1403-1412. https://doi.org/10.1016/j.bbalip.2014.06.012
Wilkerson, Brent A, and Argraves, Kelley M. "The role of sphingosine-1-phosphate in endothelial barrier function." Biochimica et biophysica acta vol. 1841,10 (2014): 1403-1412. doi: https://doi.org/10.1016/j.bbalip.2014.06.012
Wilkerson BA, Argraves KM. The role of sphingosine-1-phosphate in endothelial barrier function. Biochim Biophys Acta. 2014 Oct;1841(10):1403-1412. doi: 10.1016/j.bbalip.2014.06.012. Epub 2014 Jul 05. PMID: 25009123; PMCID: PMC4169319.
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Biochim Biophys Acta. 2014 Oct;1841(10):1403-1412. doi: 10.1016/j.bbalip.2014.06.012. Epub 2014 Jul 05.

The role of sphingosine-1-phosphate in endothelial barrier function.

Biochimica et biophysica acta

Brent A Wilkerson, Kelley M Argraves

Affiliations

  1. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Ave., BSB650, Charleston, SC 29425, USA.
  2. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Ave., BSB650, Charleston, SC 29425, USA. Electronic address: [email protected].

PMID: 25009123 PMCID: PMC4169319 DOI: 10.1016/j.bbalip.2014.06.012

Abstract

Loss of endothelial barrier function is implicated in the etiology of metastasis, atherosclerosis, sepsis and many other diseases. Studies suggest that sphingosine-1-phosphate (S1P), particularly HDL-bound S1P (HDL-S1P) is essential for endothelial barrier homeostasis and that HDL-S1P may be protective against the loss of endothelial barrier function in disease. This review summarizes evidence providing mechanistic insights into how S1P maintains endothelial barrier function, highlighting the recent findings that implicate the major S1P carrier, HDL, in the maintenance of the persistent S1P-signaling needed to maintain endothelial barrier function. We review the mechanisms proposed for HDL maintenance of persistent S1P-signaling, the evidence supporting these mechanisms and the remaining fundamental questions.

Copyright © 2014 Elsevier B.V. All rights reserved.

Keywords: Endothelial barrier function; HDL; S1P; Sphingosine-1-phosphate

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