Magn Reson Med. 2015 Jul;74(1):260-265. doi: 10.1002/mrm.25378. Epub 2014 Jul 23.
Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue.
Magnetic resonance in medicine
Ioannis Karakitsios, Osnat Dogadkin, Nhan Le, Andreas Melzer
Affiliations
Affiliations
- Institute for Medical Science and Technology, University of Dundee, Dundee, United Kingdom.
PMID: 25056821
DOI: 10.1002/mrm.25378
Abstract
PURPOSE: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS).
METHODS: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ΔΦ, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ΔT. The PRF shift coefficient was calculated from the measured ΔΦ, ΔT.
RESULTS: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10
CONCLUSION: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. Magn Reson Med 74:260-265, 2015. © 2014 Wiley Periodicals, Inc.
© 2014 Wiley Periodicals, Inc.
Keywords: MR-guided focused ultrasound; PRF shift coefficient; PRF thermometry; Thiel embalmed tissue
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