Display options
Cite
Bembich S, Clarici A, Vecchiet C, et al. Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task. Front Hum Neurosci. 2014;8:464doi: 10.3389/fnhum.2014.00464.
Bembich, S., Clarici, A., Vecchiet, C., Baldassi, G., Cont, G., & Demarini, S. (2014). Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task. Frontiers in human neuroscience, 8464. https://doi.org/10.3389/fnhum.2014.00464
Bembich, Stefano, et al. "Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task." Frontiers in human neuroscience vol. 8 (2014): 464. doi: https://doi.org/10.3389/fnhum.2014.00464
Bembich S, Clarici A, Vecchiet C, Baldassi G, Cont G, Demarini S. Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task. Front Hum Neurosci. 2014 Jun 24;8:464. doi: 10.3389/fnhum.2014.00464. eCollection 2014. PMID: 25009486; PMCID: PMC4067729.
Copy Download .nbib Format: NLM
Share it on

Front Hum Neurosci. 2014 Jun 24;8:464. doi: 10.3389/fnhum.2014.00464. eCollection 2014.

Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task.

Frontiers in human neuroscience

Stefano Bembich, Andrea Clarici, Cristina Vecchiet, Giulio Baldassi, Gabriele Cont, Sergio Demarini

Affiliations

  1. Institute for Maternal and Child Health, IRCCS "Burlo Garofolo" Trieste, Italy.
  2. Psychiatric Clinic Unit, Department of Medical, Surgical and Health Sciences, University of Trieste Trieste, Italy.

PMID: 25009486 PMCID: PMC4067729 DOI: 10.3389/fnhum.2014.00464

Abstract

Prefrontal cortex plays an important role in decision making (DM), supporting choices in the ordinary uncertainty of everyday life. To assess DM in an unpredictable situation, a playing card task, such as the Iowa Gambling Task (IGT), has been proposed. This task is supposed to specifically test emotion-based learning, linked to the integrity of the ventromedial prefrontal cortex (VMPFC). However, the dorsolateral prefrontal cortex (DLPFC) has demonstrated a role in IGT performance too. Our aim was to study, by multichannel near-infrared spectroscopy, the contribution of DLPFC to the IGT execution over time. We tested the hypothesis that low and high risk choices would differentially activate DLPFC, as IGT execution progressed. We enrolled 11 healthy adults. To identify DLPFC activation associated with IGT choices, we compared regional differences in oxy-hemoglobin variation, from baseline to the event. The time course of task execution was divided in four periods, each one consisting of 25 choices, and DLPFC activation was distinctly analyzed for low and high risk choices in each period. We found different time courses in DLPFC activation, associated with low or high risk choices. During the first period, a significant DLPFC activation emerged with low risk choices, whereas, during the second period, we found a cortical activation with high risk choices. Then, DLPFC activation decreased to non-significant levels during the third and fourth period. This study shows that DLPFC involvement in IGT execution is differentiated over time and according to choice risk level. DLPFC is activated only in the first half of the task, earlier by low risk and later by high risk choices. We speculate that DLPFC may sustain initial and more cognitive functions, such as attention shifting and response inhibition. The lack of DLPFC activation, as the task progresses, may be due to VMPFC activation, not detectable by fNIRS, which takes over the IGT execution in its second half.

Keywords: DLPFC; Iowa Gambling Task; attention shifting; multichannel NIRS; response inhibition; risk

References

  1. Rev Neurol. 2006 Apr 1-15;42(7):411-8 - PubMed
  2. Neuropsychol Rev. 2009 Mar;19(1):102-14 - PubMed
  3. Med Phys. 2001 Apr;28(4):521-7 - PubMed
  4. Cereb Cortex. 2005 Jan;15(1):58-63 - PubMed
  5. Eur J Neurosci. 2009 Jan;29(1):181-7 - PubMed
  6. Brain. 2000 Nov;123 ( Pt 11):2189-202 - PubMed
  7. Cognition. 1994 Apr-Jun;50(1-3):7-15 - PubMed
  8. Trends Neurosci. 2008 Dec;31(12):599-608 - PubMed
  9. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8351-6 - PubMed
  10. Am J Psychiatry. 2003 Jun;160(6):1061-70 - PubMed
  11. BMC Neurosci. 2008 Jul 26;9:72 - PubMed
  12. Neuroimage. 2003 Jul;19(3):1085-94 - PubMed
  13. Brain. 2003 Aug;126(Pt 8):1790-800 - PubMed
  14. Brain Cogn. 2008 Apr;66(3):253-9 - PubMed
  15. Cereb Cortex. 2009 May;19(5):1134-43 - PubMed
  16. Med Phys. 1995 Dec;22(12):1997-2005 - PubMed
  17. Neuropsychologia. 2003;41(11):1474-83 - PubMed
  18. Neuroimage. 2002 Apr;15(4):870-8 - PubMed
  19. Neuroimage. 2005 Jun;26(2):480-92 - PubMed
  20. Neuropsychologia. 2010 Apr;48(5):1438-46 - PubMed
  21. Neuroimage. 2009 Jan 15;44(2):428-47 - PubMed
  22. Neuroimage. 2001 Mar;13(3):520-30 - PubMed
  23. Neuroimage. 2007 Feb 15;34(4):1506-18 - PubMed
  24. Semin Clin Neuropsychiatry. 2001 Jul;6(3):205-16 - PubMed
  25. J Neurosci. 2008 Aug 6;28(32):8053-62 - PubMed
  26. Neuroimage. 2005 Oct 1;27(4):842-51 - PubMed
  27. Brain. 2002 Mar;125(Pt 3):624-39 - PubMed
  28. Neuroimage. 2002 Jan;15(1):273-89 - PubMed
  29. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14681-6 - PubMed
  30. Neuropsychologia. 2009 Jun;47(7):1686-93 - PubMed
  31. Eur J Neurosci. 2012 Apr;35(7):1075-82 - PubMed
  32. Cereb Cortex. 2000 Mar;10(3):295-307 - PubMed
  33. Neuroimage. 2006 Nov 1;33(2):542-9 - PubMed
  34. Neuroimage. 2004 May;22(1):341-6 - PubMed
  35. J Biomed Opt. 2000 Oct;5(4):383-90 - PubMed
  36. Neuroimage. 2012 Sep;62(3):1896-911 - PubMed
  37. Electroencephalogr Clin Neurophysiol Suppl. 1999;52:3-6 - PubMed
  38. Cereb Cortex. 2000 Mar;10(3):308-17 - PubMed
  39. Neuroimage. 2002 Oct;17(2):719-31 - PubMed
  40. J Neurosci. 2009 Sep 2;29(35):11020-8 - PubMed
  41. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10722-7 - PubMed
  42. J Neurosci. 2010 May 12;30(19):6613-9 - PubMed
  43. Neuropsychologia. 1971 Mar;9(1):97-113 - PubMed
  44. Neuropsychopharmacology. 2002 May;26(5):682-91 - PubMed
  45. J Neurosci. 1999 Jul 1;19(13):5473-81 - PubMed
  46. J Neurosci. 1998 Jan 1;18(1):428-37 - PubMed

Publication Types