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Pesce L, Kopp P. Iodide transport: implications for health and disease. Int J Pediatr Endocrinol. 2014;2014(1):8doi: 10.1186/1687-9856-2014-8.
Pesce, L., & Kopp, P. (2014). Iodide transport: implications for health and disease. International journal of pediatric endocrinology, 2014(1), 8. https://doi.org/10.1186/1687-9856-2014-8
Pesce, Liuska, and Kopp, Peter. "Iodide transport: implications for health and disease." International journal of pediatric endocrinology vol. 2014,1 (2014): 8. doi: https://doi.org/10.1186/1687-9856-2014-8
Pesce L, Kopp P. Iodide transport: implications for health and disease. Int J Pediatr Endocrinol. 2014;2014(1):8. doi: 10.1186/1687-9856-2014-8. Epub 2014 May 30. PMID: 25009573; PMCID: PMC4089555.
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Int J Pediatr Endocrinol. 2014;2014(1):8. doi: 10.1186/1687-9856-2014-8. Epub 2014 May 30.

Iodide transport: implications for health and disease.

International journal of pediatric endocrinology

Liuska Pesce, Peter Kopp

Affiliations

  1. Stead Family Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Iowa Carver School of Medicine, Iowa City, Iowa 52242, USA.
  2. Department of Internal Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

PMID: 25009573 PMCID: PMC4089555 DOI: 10.1186/1687-9856-2014-8

Abstract

Disorders of the thyroid gland are among the most common conditions diagnosed and managed by pediatric endocrinologists. Thyroid hormone synthesis depends on normal iodide transport and knowledge of its regulation is fundamental to understand the etiology and management of congenital and acquired thyroid conditions such as hypothyroidism and hyperthyroidism. The ability of the thyroid to concentrate iodine is also widely used as a tool for the diagnosis of thyroid diseases and in the management and follow up of the most common type of endocrine cancers: papillary and follicular thyroid cancer. More recently, the regulation of iodide transport has also been the center of attention to improve the management of poorly differentiated thyroid cancer. Iodine deficiency disorders (goiter, impaired mental development) due to insufficient nutritional intake remain a universal public health problem. Thyroid function can also be influenced by medications that contain iodide or interfere with iodide metabolism such as iodinated contrast agents, povidone, lithium and amiodarone. In addition, some environmental pollutants such as perchlorate, thiocyanate and nitrates may affect iodide transport. Furthermore, nuclear accidents increase the risk of developing thyroid cancer and the therapy used to prevent exposure to these isotopes relies on the ability of the thyroid to concentrate iodine. The array of disorders involving iodide transport affect individuals during the whole life span and, if undiagnosed or improperly managed, they can have a profound impact on growth, metabolism, cognitive development and quality of life.

Keywords: Hyperthyroidism; Hypothyroidism; Iodide transport; Iodine; Iodine deficiency; Radioactive iodine; Thyroid; Thyroid cancer; Thyroid hormones

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