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Lee HY, Lim KH, Ryu Y, et al. Bleomycin-induced flagellate erythema: A case report and review of the literature. Oncol Lett. 2014;8(2):933-935doi: 10.3892/ol.2014.2179.
Lee, H. Y., Lim, K. H., Ryu, Y., & Song, S. Y. (2014). Bleomycin-induced flagellate erythema: A case report and review of the literature. Oncology letters, 8(2), 933-935. https://doi.org/10.3892/ol.2014.2179
Lee, Hui-Young, et al. "Bleomycin-induced flagellate erythema: A case report and review of the literature." Oncology letters vol. 8,2 (2014): 933-935. doi: https://doi.org/10.3892/ol.2014.2179
Lee HY, Lim KH, Ryu Y, Song SY. Bleomycin-induced flagellate erythema: A case report and review of the literature. Oncol Lett. 2014 Aug;8(2):933-935. doi: 10.3892/ol.2014.2179. Epub 2014 May 26. PMID: 25009666; PMCID: PMC4081419.
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Oncol Lett. 2014 Aug;8(2):933-935. doi: 10.3892/ol.2014.2179. Epub 2014 May 26.

Bleomycin-induced flagellate erythema: A case report and review of the literature.

Oncology letters

Hui-Young Lee, Kyu-Hyoung Lim, Youngjoon Ryu, Seo-Young Song

Affiliations

  1. Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-947, Republic of Korea.
  2. Department of Pathology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-947, Republic of Korea.

PMID: 25009666 PMCID: PMC4081419 DOI: 10.3892/ol.2014.2179

Abstract

Bleomycin has been used most commonly in the treatment of Hodgkin's lymphoma, certain germ cell tumors (GCT) and for the sclerosis of recurrent pleural effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity includes Raynaud's phenomenon, hyperkeratosis, nail-bed changes and palmoplantar desquamation. Flagellate erythema is an unusual rash occurring specifically during bleomycin use. In the present study, we report a case of bleomycin-induced flagellate erythema in a patient with GCT. A 42-year-old male was diagnosed with stage IIIB testicular cancer and treated with bleomycin, etoposide and cisplatin chemotherapy. After 10 days from the initiation of treatment, the patient subsequently developed a generalized pruritus and erythematous linear rash that was most prominent on the trunk, and upper and lower extremities. The patient was commenced on a short course of low-dose oral prednisolone, 20 mg daily, and antihistamine. Consequently, bleomycin was withheld from the patient's treatment regimen. The present study describes the case, along with a review of the associated literature.

Keywords: bleomycin; flagellate erythema; skin toxicity

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