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Shah AF, Tangade P, Agarwal S. Papillon-Lefevre syndrome: Reporting consanguinity as a risk factor. Saudi Dent J. 2014;26(3):126-31doi: 10.1016/j.sdentj.2014.02.004.
Shah, A. F., Tangade, P., & Agarwal, S. (2014). Papillon-Lefevre syndrome: Reporting consanguinity as a risk factor. The Saudi dental journal, 26(3), 126-31. https://doi.org/10.1016/j.sdentj.2014.02.004
Shah, Aasim Farooq, et al. "Papillon-Lefevre syndrome: Reporting consanguinity as a risk factor." The Saudi dental journal vol. 26,3 (2014): 126-31. doi: https://doi.org/10.1016/j.sdentj.2014.02.004
Shah AF, Tangade P, Agarwal S. Papillon-Lefevre syndrome: Reporting consanguinity as a risk factor. Saudi Dent J. 2014 Jul;26(3):126-31. doi: 10.1016/j.sdentj.2014.02.004. Epub 2014 Apr 19. PMID: 25057233; PMCID: PMC4095039.
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Saudi Dent J. 2014 Jul;26(3):126-31. doi: 10.1016/j.sdentj.2014.02.004. Epub 2014 Apr 19.

Papillon-Lefevre syndrome: Reporting consanguinity as a risk factor.

The Saudi dental journal

Aasim Farooq Shah, Pradeep Tangade, Swatantra Agarwal

Affiliations

  1. Department of Public Health Dentistry, Kothiwal Dental College & Research Centre, Kanth Road, Moradabad 244001, Uttar Pradesh, India.
  2. Department of Prosthodontics, Kothiwal Dental College & Research Centre, Kanth Road, Moradabad 244001, Uttar Pradesh, India.

PMID: 25057233 PMCID: PMC4095039 DOI: 10.1016/j.sdentj.2014.02.004

Abstract

Papillon-Lefevre syndrome (PLS) is an autosomal recessive genetic disorder characterized by palmoplantar hyperkeratosis associated with severe early-onset periodontitis and premature loss of primary and permanent teeth. This report describes two cases of PLS in 28-year-old female and 16-year-old male siblings with consanguineously married parents. The patients presented to the Department of Public Health Dentistry of a dental education and research institute in India with thickening, flaking, and scaling of the skin on the palms and soles of the feet. On oral examination, the female patient presented completely resorbed maxillary and mandibular alveolar ridges with retention of only the third molars. The male patient retained only teeth 18, 13, 28, 38, and 45. Based on complete histories and clinical examination findings, a final diagnosis of PLS was made and treatment was initiated using an interdisciplinary dental approach in both cases.

Keywords: Consanguinity; Papillon–Lefevre syndrome; Periodontitis; Premature tooth loss

References

  1. Nat Genet. 1999 Dec;23(4):421-4 - PubMed
  2. J Oral Med. 1985 Jan-Mar;40(1):43-5 - PubMed
  3. P R Health Sci J. 1997 Sep;16(3):279-81 - PubMed
  4. J Clin Periodontol. 2000 Jan;27(1):69-73 - PubMed
  5. Clin Immunol Immunopathol. 1984 Jun;31(3):419-29 - PubMed
  6. J Clin Periodontol. 1993 Oct;20(9):662-7 - PubMed
  7. Pediatrics. 2003 Jan;111(1):e85-8 - PubMed
  8. Int J Dermatol. 1988 Jan-Feb;27(1):63-6 - PubMed
  9. J Am Acad Dermatol. 2002 Feb;46(2 Suppl Case Reports):S8-10 - PubMed
  10. J Indian Soc Periodontol. 2010 Oct;14(4):275-8 - PubMed
  11. Arch Dermatol. 1996 Jun;132(6):640-51 - PubMed
  12. Br J Dermatol. 1988 Dec;119(6):731-6 - PubMed
  13. Indian J Dent Res. 2007 Oct-Dec;18(4):210-3 - PubMed
  14. J Dent Res. 2005 May;84(5):414-7 - PubMed
  15. Blood. 2006 May 1;107(9):3665-8 - PubMed
  16. J Med Genet. 2000 Dec;37(12):927-32 - PubMed
  17. J Periodontol. 1993 May;64(5):379-86 - PubMed
  18. Nat Rev Genet. 2002 Mar;3(3):225-9 - PubMed
  19. J Med Genet. 2001 Feb;38(2):96-101 - PubMed
  20. J Med Genet. 1999 Dec;36(12):881-7 - PubMed
  21. J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S240-3 - PubMed
  22. J Int Acad Periodontol. 2008 Jul;10(3):81-6 - PubMed
  23. J Am Acad Dermatol. 2003 Mar;48(3):345-51 - PubMed
  24. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Dec;100(6):709-16 - PubMed
  25. Ann Hum Biol. 2002 Jul-Aug;29(4):422-31 - PubMed
  26. J Clin Periodontol. 1996 Mar;23(3 Pt 1):176-9 - PubMed
  27. J Indian Soc Periodontol. 2012 Apr;16(2):261-5 - PubMed
  28. J Indian Soc Periodontol. 2013 May;17(3):373-7 - PubMed

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