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Sanchez AA, Singh GK. Early ventricular remodeling and dysfunction in obese children and adolescents. Curr Treat Options Cardiovasc Med. 2014;16(10):340doi: 10.1007/s11936-014-0340-3.
Sanchez, A. A., & Singh, G. K. (2014). Early ventricular remodeling and dysfunction in obese children and adolescents. Current treatment options in cardiovascular medicine, 16(10), 340. https://doi.org/10.1007/s11936-014-0340-3
Sanchez, Aura A, and Singh, Gautam K. "Early ventricular remodeling and dysfunction in obese children and adolescents." Current treatment options in cardiovascular medicine vol. 16,10 (2014): 340. doi: https://doi.org/10.1007/s11936-014-0340-3
Sanchez AA, Singh GK. Early ventricular remodeling and dysfunction in obese children and adolescents. Curr Treat Options Cardiovasc Med. 2014 Oct;16(10):340. doi: 10.1007/s11936-014-0340-3. PMID: 25143118.
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Curr Treat Options Cardiovasc Med. 2014 Oct;16(10):340. doi: 10.1007/s11936-014-0340-3.

Early ventricular remodeling and dysfunction in obese children and adolescents.

Current treatment options in cardiovascular medicine

Aura A Sanchez, Gautam K Singh

Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, One Children's Place, Campus Box 8116-NWT, St. Louis, MO, 63110, USA.

PMID: 25143118 DOI: 10.1007/s11936-014-0340-3

Abstract

OPINION STATEMENT: Obesity is an independent predictor of heart failure in adults. Obese individuals have increased hemodynamic load and neuro-hormonal activation that contribute, but cannot entirely explain the reported changes in ventricular structure and function leading to heart failure. There are intrinsic alterations in the myocardium that are independent of load. Insulin resistance promotes alterations in myocardial substrate metabolism that may play a role in the pathogenesis of decreased myocardial efficiency and cardiac dysfunction in obese individuals. The prevalence of obesity in childhood and adolescence has increased significantly over the last decade. Obese children and adolescents have left ventricular remodeling that transpires into adulthood, and subclinical systolic and diastolic dysfunction despite normal conventional parameters of ventricular function. These findings suggest that obesity has an early impact in the cardiovascular health of obese adolescents. Life-style modifications causing weight loss can reverse the ventricular dysfunction observed in this young population and must be strongly encouraged.

References

  1. JAMA. 2010 Nov 10;304(18):2042-7 - PubMed
  2. J Am Coll Cardiol. 1992 Nov 1;20(5):1251-60 - PubMed
  3. J Am Soc Echocardiogr. 2012 Apr;25(4):401-410.e1 - PubMed
  4. JAMA. 2012 Feb 1;307(5):483-90 - PubMed
  5. Arch Pediatr Adolesc Med. 2010 Sep;164(9):852-9 - PubMed
  6. Int J Obes Relat Metab Disord. 1995 Aug;19(8):550-7 - PubMed
  7. J Am Coll Cardiol. 2013 Apr 23;61(16):1698-706 - PubMed
  8. Eur Heart J Cardiovasc Imaging. 2013 Jul;14(7):668-76 - PubMed
  9. J Am Soc Echocardiogr. 2009 Jun;22(6):709-14 - PubMed
  10. Eur Heart J Cardiovasc Imaging. 2013 Sep;14(9):882-9 - PubMed
  11. Am J Hypertens. 2002 May;15(5):381-8 - PubMed
  12. Endocrinology. 2004 May;145(5):2273-82 - PubMed
  13. Biochim Biophys Acta. 2010 Mar;1801(3):311-9 - PubMed
  14. Diabetes Care. 2000 May;23(5):624-8 - PubMed
  15. Nat Clin Pract Cardiovasc Med. 2007 Aug;4(8):436-43 - PubMed
  16. Obesity (Silver Spring). 2011 Nov;19(11):2268-73 - PubMed
  17. Am J Med Sci. 2001 Apr;321(4):225-36 - PubMed
  18. Nutr Metab Cardiovasc Dis. 2008 Nov;18(9):613-7 - PubMed
  19. Circulation. 2010 Jan 19;121(2):230-6 - PubMed
  20. J Am Coll Cardiol. 2006 Jun 6;47(11):2267-73 - PubMed
  21. Natl Health Stat Report. 2010 Jun 25;(25):1-5 - PubMed
  22. J Pediatr. 2011 May;158(5):709-714.e1 - PubMed
  23. J Am Coll Cardiol. 1996 Feb;27(2):277-84 - PubMed
  24. Eur J Echocardiogr. 2011 Mar;12(3):167-205 - PubMed
  25. Int J Cardiol. 2013 Oct 3;168(3):2347-51 - PubMed
  26. Int J Obes (Lond). 2008 Dec;32 Suppl 7:S13-8 - PubMed
  27. J Am Coll Cardiol. 2011 Jun 21;57(25):2461-73 - PubMed
  28. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv166-71 - PubMed
  29. J Am Soc Echocardiogr. 2010 Nov;23(11):1190-8 - PubMed
  30. Am J Cardiol. 2014 Mar 15;113(6):1054-7 - PubMed
  31. JAMA. 2003 Nov 5;290(17):2271-6 - PubMed
  32. J Mol Cell Cardiol. 1999 May;31(5):949-70 - PubMed
  33. Eur J Echocardiogr. 2006 Mar;7(2):79-108 - PubMed
  34. Am J Cardiol. 2006 Aug 1;98(3):411-5 - PubMed
  35. Circ Res. 2012 Dec 7;111(12):1565-77 - PubMed
  36. Int J Cardiol. 2008 Nov 28;130(3):319-25 - PubMed
  37. J Am Coll Cardiol. 2008 Apr 8;51(14):1342-8 - PubMed
  38. Am J Cardiol. 1995 Dec 1;76(16):1194-7 - PubMed
  39. N Engl J Med. 2002 Aug 1;347(5):305-13 - PubMed
  40. Eur Heart J. 2006 Nov;27(22):2689-95 - PubMed
  41. Pediatr Int. 2010 Apr;52(2):218-23 - PubMed
  42. Circulation. 1998 May 19;97(19):1907-11 - PubMed
  43. Pediatrics. 2007 Jul;120(1):e215-9 - PubMed
  44. Pediatrics. 2007 Jul;120(1):e189-214 - PubMed
  45. Am J Clin Nutr. 2005 Apr;81(4):757-61 - PubMed
  46. Obesity (Silver Spring). 2013 Oct;21(10):2091-8 - PubMed
  47. Obesity (Silver Spring). 2012 Dec;20(12):2397-405 - PubMed
  48. Expert Rev Cardiovasc Ther. 2008 Mar;6(3):343-68 - PubMed
  49. J Am Coll Cardiol. 2004 Apr 21;43(8):1399-404 - PubMed
  50. Diabetes. 2002 Oct;51(10):3113-9 - PubMed
  51. J Am Soc Echocardiogr. 2010 Apr;23(4):351-69; quiz 453-5 - PubMed

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