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Curr Infect Dis Rep. 2014 Sep;16(9):424. doi: 10.1007/s11908-014-0424-y.

HIV and Stem Cell Transplantation.

Current infectious disease reports

Ignacio A Echenique, George E Nelson, Valentina Stosor, Christine M Durand

Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 N. Michigan Ave, Suite 900, Chicago, IL, 60611, USA, [email protected].

PMID: 25120135 DOI: 10.1007/s11908-014-0424-y

Abstract

In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug-drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.

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