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Duron E, Vidal JS, Bounatiro S, et al. Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment. Front Aging Neurosci. 2014;6:195doi: 10.3389/fnagi.2014.00195.
Duron, E., Vidal, J. S., Bounatiro, S., Ben Ahmed, S., Seux, M. L., Rigaud, A. S., Hanon, O., Viollet, C., Epelbaum, J., & Martel, G. (2014). Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment. Frontiers in aging neuroscience, 6195. https://doi.org/10.3389/fnagi.2014.00195
Duron, Emmanuelle, et al. "Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment." Frontiers in aging neuroscience vol. 6 (2014): 195. doi: https://doi.org/10.3389/fnagi.2014.00195
Duron E, Vidal JS, Bounatiro S, Ben Ahmed S, Seux ML, Rigaud AS, Hanon O, Viollet C, Epelbaum J, Martel G. Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment. Front Aging Neurosci. 2014 Jul 29;6:195. doi: 10.3389/fnagi.2014.00195. eCollection 2014. PMID: 25120483; PMCID: PMC4114211.
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Front Aging Neurosci. 2014 Jul 29;6:195. doi: 10.3389/fnagi.2014.00195. eCollection 2014.

Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment.

Frontiers in aging neuroscience

Emmanuelle Duron, Jean-Sébastien Vidal, Samira Bounatiro, Sana Ben Ahmed, Marie-Laure Seux, Anne-Sophie Rigaud, Olivier Hanon, Cécile Viollet, Jacques Epelbaum, Guillaume Martel

Affiliations

  1. Service de Gériatrie, Hôpital Broca, Assistance Publique - Hôpitaux de Paris , Paris , France ; Université Paris Descartes, Sorbonne Paris Cité, Equipe d'Accueil 4468 , Paris , France.
  2. UMRS 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité , Paris , France.

PMID: 25120483 PMCID: PMC4114211 DOI: 10.3389/fnagi.2014.00195

Abstract

Mild cognitive impairment (MCI) is a heterogeneous cognitive status that can be a prodromal stage of Alzheimer's disease (AD). It is particularly relevant to focus on prodromal stages of AD such as MCI, because patho-physiological abnormalities of AD start years before the dementia stage. Medial temporal lobe (MTL) atrophy resulting from AD lesions and cerebrovascular lesions [i.e., white matter lesions (WML), lacunar strokes, and strokes] are often revealed concurrently on magnetic resonance imaging (MRI) in MCI subjects. Personality changes have been reported to be associated with MCI status and early AD. More specifically, an increase in neuroticism and a decrease in conscientiousness have been reported, suggesting that higher and lower scores, respectively, in neuroticism and conscientiousness are associated with an increased risk of developing the disease. However, personality changes have not been studied concomitantly with pathological structural brain alterations detected on MRI in patients suffering from MCI. Therefore, the objective of the present study was to assess the relationship between MTL atrophy, WML, lacunar strokes, and personality traits in such patients. The severity of WML was strongly associated with lower levels of conscientiousness and higher levels of neuroticism. Conversely, no association was detected between personality traits and the presence of lacunar strokes or MTL atrophy. Altogether, these results strongly suggest that personality changes occurring in a MCI population, at high risk of AD, are associated with WML, which can induce executive dysfunctions, rather than with MTL atrophy.

Keywords: Alzheimer; WML; conscientiousness; leukoaraiosis; medial temporal lobe; mild cognitive impairment; neuroticism

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