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Holland J, Chandurkar V. A retrospective study of surgically excised phaeochromocytomas in Newfoundland, Canada. Indian J Endocrinol Metab. 2014;18(4):542-5doi: 10.4103/2230-8210.137514.
Holland, J., & Chandurkar, V. (2014). A retrospective study of surgically excised phaeochromocytomas in Newfoundland, Canada. Indian journal of endocrinology and metabolism, 18(4), 542-5. https://doi.org/10.4103/2230-8210.137514
Holland, Joanna, and Chandurkar, Vikram. "A retrospective study of surgically excised phaeochromocytomas in Newfoundland, Canada." Indian journal of endocrinology and metabolism vol. 18,4 (2014): 542-5. doi: https://doi.org/10.4103/2230-8210.137514
Holland J, Chandurkar V. A retrospective study of surgically excised phaeochromocytomas in Newfoundland, Canada. Indian J Endocrinol Metab. 2014 Jul;18(4):542-5. doi: 10.4103/2230-8210.137514. PMID: 25143914; PMCID: PMC4138913.
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Indian J Endocrinol Metab. 2014 Jul;18(4):542-5. doi: 10.4103/2230-8210.137514.

A retrospective study of surgically excised phaeochromocytomas in Newfoundland, Canada.

Indian journal of endocrinology and metabolism

Joanna Holland, Vikram Chandurkar

Affiliations

  1. Fellow, Endocrinology, University of Alberta, Edmonton, Canada.
  2. Assistant Professor, Division of Endocrinology, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Center, St. John's, NL, Canada.

PMID: 25143914 PMCID: PMC4138913 DOI: 10.4103/2230-8210.137514

Abstract

OBJECTIVE: A retrospective study detailing the circumstances surrounding diagnosis and treatment of pheochromocytomas with the associated genetic disorders.

MATERIALS AND METHODS: All patients with surgically excised pheochromocytomas in the Health Sciences Center, St. John's, Newfoundland, Canada between January 2001 and December 2010 were retrospectively analyzed to determine associated familial syndromes, age, tumor size, symptomatology, and percentage of paragangliomas and bilateral pheochromocytomas. Pathology specimen reports, adrenalectomy lists and Meditech (electronic medical record) diagnostic codes provided a comprehensive database for this study.

RESULTS: Twenty-four patients were studied; familial disorder patients comprised 42% (10/24). Average age at diagnosis was 57 among the sporadic and 34 in familial disorder groups (P = 0.006). Average tumor size was 4.5 cm in the sporadic group and 3 cm in the familial disorder group (P = 0.19). All atypical cases including bilateral or extra-adrenal tumors and malignancy occurred in familial disorder patients.

CONCLUSIONS: The proportion of familial disorder patients (42%) was higher in this study than would be expected, likely a result of the relatively high incidence of hereditary autosomal dominant disorders within Newfoundland. Among familial disorder patients, the average younger age at diagnosis and the smaller tumor size suggest syndromic pheochromocytomas may develop earlier, however they are more likely to be diagnosed sooner due to biochemical surveillance testing in known genetic disorder patients. We also demonstrate a relatively high incidence of surgically resected pheochromocytomas of 4.679/million/year in Newfoundland.

Keywords: Familial; Newfoundland; phaeochromocytoma; von hippel lindau

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