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Sun P, Piao H, Guo X, et al. Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report. Exp Ther Med. 2014;8(3):925-928doi: 10.3892/etm.2014.1807.
Sun, P., Piao, H., Guo, X., Wang, Z., Sui, R., Zhang, Y., Yao, B., & Chen, Y. (2014). Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report. Experimental and therapeutic medicine, 8(3), 925-928. https://doi.org/10.3892/etm.2014.1807
Sun, Peixin, et al. "Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report." Experimental and therapeutic medicine vol. 8,3 (2014): 925-928. doi: https://doi.org/10.3892/etm.2014.1807
Sun P, Piao H, Guo X, Wang Z, Sui R, Zhang Y, Yao B, Chen Y. Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report. Exp Ther Med. 2014 Sep;8(3):925-928. doi: 10.3892/etm.2014.1807. Epub 2014 Jun 24. PMID: 25120625; PMCID: PMC4113524.
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Exp Ther Med. 2014 Sep;8(3):925-928. doi: 10.3892/etm.2014.1807. Epub 2014 Jun 24.

Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report.

Experimental and therapeutic medicine

Peixin Sun, Haozhe Piao, Xu Guo, Zhengrong Wang, Rui Sui, Ye Zhang, Bing Yao, Yi Chen

Affiliations

  1. Department of Neurosurgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.
  2. Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.

PMID: 25120625 PMCID: PMC4113524 DOI: 10.3892/etm.2014.1807

Abstract

Gliomatosis cerebri (GC) is a rare glial neoplasm, characterized by extensive diffuse brain infiltration and relative preservation of the underlying architecture. In the present case report, a patient with type 2 GC, which mimicked the clinicoradiological course of acute viral encephalitis, is presented. A 56-year-old male presented with fever, dizziness, headache and numbness in the right extremities three days prior to admission to hospital. The cerebrospinal fluid (CSF) showed mild pleocytosis. Brain magnetic resonance imaging (MRI) revealed hyperintensity on fluid-attenuated inversion recovery images in the left frontal, temporal, insular lobes and in the left thalamus. No signal enhancement was observed following gadolinium administration. The patient was diagnosed with acute viral encephalitis of unknown cause and received a 10-day course of acyclovir, intravenously. At the follow-up three months later, the patient had personality changes and memory deterioration. The results from the follow-up MRI revealed no remarkable changes. At the follow-up six months after presentation, the patient had expressive aphasia and severe headaches. Subsequently, the patient had two tonic-clonic seizure onsets. The results from the MRI showed an increase in lesion size, more edema around the lesion and irregular enhancement in the left frontal lobe. However, the lesions in the left temporal and insular lobes and in the left thalamus were nearly unchanged. Magnetic resonance spectroscopy (MRS) showed elevated choline (Cho)/creatine (Cr) and Cho/

Keywords: gliomatosis cerebri; malignant transformation; viral encephalitis

References

  1. Acta Neuropathol. 2003 Jun;105(6):529-36 - PubMed
  2. Eur J Radiol. 2006 Aug;59(2):216-21 - PubMed
  3. Curr Treat Options Neurol. 2014 Feb;16(2):273 - PubMed
  4. Clin Neurol Neurosurg. 2012 May;114(4):299-306 - PubMed
  5. Acta Neurochir (Wien). 1998;140(8):755-62 - PubMed
  6. Intern Med. 2010;49(13):1307-10 - PubMed
  7. Postgrad Med J. 1999 Dec;75(890):727-30 - PubMed
  8. Lancet. 2002 Feb 9;359(9305):507-13 - PubMed

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