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Bae SH, Park HS, Han HS, et al. Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity. Pediatr Gastroenterol Hepatol Nutr. 2014;17(2):121-4doi: 10.5223/pghn.2014.17.2.121.
Bae, S. H., Park, H. S., Han, H. S., & Yun, I. J. (2014). Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity. Pediatric gastroenterology, hepatology & nutrition, 17(2), 121-4. https://doi.org/10.5223/pghn.2014.17.2.121
Bae, Sun Hwan, et al. "Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity." Pediatric gastroenterology, hepatology & nutrition vol. 17,2 (2014): 121-4. doi: https://doi.org/10.5223/pghn.2014.17.2.121
Bae SH, Park HS, Han HS, Yun IJ. Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity. Pediatr Gastroenterol Hepatol Nutr. 2014 Jun;17(2):121-4. doi: 10.5223/pghn.2014.17.2.121. Epub 2014 Jun 30. PMID: 25061589; PMCID: PMC4107220.
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Pediatr Gastroenterol Hepatol Nutr. 2014 Jun;17(2):121-4. doi: 10.5223/pghn.2014.17.2.121. Epub 2014 Jun 30.

Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity.

Pediatric gastroenterology, hepatology & nutrition

Sun Hwan Bae, Hee Sun Park, Hye Seung Han, Ik Jin Yun

Affiliations

  1. Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
  2. Department of Radiology, Konkuk University School of Medicine, Seoul, Korea.
  3. Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
  4. Department of General Surgery, Konkuk University School of Medicine, Seoul, Korea.

PMID: 25061589 PMCID: PMC4107220 DOI: 10.5223/pghn.2014.17.2.121

Abstract

Omega (ω)-3 polyunsaturated fatty acids appear to be effective in preventing and treating parenteral nutrition-associated liver disease, and several mechanisms were proposed for this observation. An 8-week-old male infant with cholestasis and acholic stool was diagnosed non-syndromic intrahepatic interlobular bile duct paucity by open-wedge liver biopsy. Initially he was treated with usual supportive medical therapy, including ursodeoxycholic acid. However, the clinical status and laboratory tests did not improve. Omega (ω)-3 polyunsaturated fatty acids (initially intravenous administration and oral administration later), were started and his liver function, including aminotransferase level and bilirubin levels normalized, and the ivory stool color turned green. We report the possible effectiveness of ω-3 polyunsaturated fatty acids as a potent choleretic agent for non-syndromic intrahepatic interlobular bile duct paucity, a very rare structural pediatric hepatic disease.

Keywords: Bile duct paucity; Cholestasis; Infant; Omega-3 fatty acids

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