Iran J Reprod Med. 2014 May;12(5):357-60.

Association of heteromorphism of chromosome 9 and recurrent abortion (ultrasound diagnosed blighted ovum): A case report.

Iranian journal of reproductive medicine

Fatemeh Baghbani, Salmeh Mirzaee, Mohammad Hassanzadeh-Nazarabadi

PMID: 25031581 PMCID: PMC4094662

Abstract

BACKGROUND: Chromosomal disorders are the most common cause of first trimester spontaneous abortion. Among the human chromosomes, chromosome no.9 was the most common structural chromosomal variant and it is not thought to be of any functional importance, which often considers as a normal variation in structural polymorphisms, nevertheless there are some studies which claim that there is an association between heteromorphism of chromosome no.9 and some pregnancy complication.

CASE: To postulate any correlation between chromosome no. 9 heteromorphism and recurrent abortion, chromosomal analysis was performed on the basis of G-banding technique at high resolution for a couple with the history of 4 ultrasound diagnosed blighted ovum and Chromosome constitution appeared with chromosome no.9 heteromorphism in all 30 metaphases screened for both partners (9p11-q13).

CONCLUSION: Observation of reproductive failure in couples with heteromorohic pattern of chromosome no.9 suggests that, although the heteromorphism of chromosome no.9 is not a rare condition which often consider as a normal variation with no evidence of any phenotypic effect of patient, nevertheless it seems as if the location of heteromorphic region maybe interfere with meiotic events like the phenomenon of crossing over or miotic segregation of fertilized egg that eventually lead to the development of fertilized eggs with chromosomal abnormalities leading to the possibility of anemberyonic pregnancy, therefore chromosomal analysis for detecting of chromosome no.9 heteromorphism for couples with the history of ultrasound diagnosed blighted ovum will be strongly suggested.

Keywords: Blighted ovum; Chromosome no. 9; Heteromorphism; Pregnancy complication; Recurrent abortion

References

1. Prenat Diagn. 2008 May;28(5):408-11 - PubMed
2. Fetal Diagn Ther. 1998 May-Jun;13(3):187-91 - PubMed
3. Obstet Gynecol. 2005 May;105(5 Pt 1):1104-13 - PubMed
4. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Oct;14(5):855-65 - PubMed
5. Am J Hum Genet. 1975 Mar;27(2):178-89 - PubMed
6. Arch Androl. 2003 Jan-Feb;49(1):49-55 - PubMed
7. Mol Cytogenet. 2013 Apr 01;6(1):14 - PubMed
8. BMJ. 2005 Jul 16;331(7509):137-41 - PubMed
9. Reprod Biomed Online. 2005 Dec;11(6):726-32 - PubMed
10. Rom J Morphol Embryol. 2013;54(2):377-83 - PubMed
11. Acta Eur Fertil. 1981 Sep;12(3):245-8 - PubMed
12. Hum Reprod. 2002 Dec;17(12):3201-7 - PubMed
13. Clin Obstet Gynecol. 1986 Dec;29(4):865-85 - PubMed
14. Fertil Steril. 2007 Sep;88(3):721-3 - PubMed
15. J Clin Ultrasound. 2002 Mar-Apr;30(3):161-77 - PubMed
16. Ultrasound Obstet Gynecol. 1996 Mar;7(3):170-3 - PubMed
17. Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):127-31 - PubMed
18. Maedica (Bucur). 2012 Jan;7(1):25-9 - PubMed
19. Nature. 2004 May 27;429(6990):369-74 - PubMed

Publication Types

• Case Reports