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Viswanathan V, Phadatare AG, Mukne A. Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian J Pharm Sci. 2014;76(3):256-61
Viswanathan, V., Phadatare, A. G., & Mukne, A. (2014). Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian journal of pharmaceutical sciences, 76(3), 256-61.
Viswanathan, V, et al. "Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs." Indian journal of pharmaceutical sciences vol. 76,3 (2014): 256-61.
Viswanathan V, Phadatare AG, Mukne A. Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian J Pharm Sci. 2014 May;76(3):256-61. PMID: 25035540; PMCID: PMC4090836.
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Indian J Pharm Sci. 2014 May;76(3):256-61.

Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.

Indian journal of pharmaceutical sciences

V Viswanathan, A G Phadatare, Alka Mukne

Affiliations

  1. Department of Pharmacognosy, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098, India.

PMID: 25035540 PMCID: PMC4090836

Abstract

Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human history as a medicinal plant. Garlic contains sulfur compounds like allicin, ajoene, allylmethyltrisulfide, diallyltrisulfide, diallyldisulphide and others which exhibit various biological properties like antimicrobial, anticancer, antioxidant, immunomodulatory, antiinflammatory, hypoglycemic, and cardiovascular effects. According to various traditional systems of medicine, garlic is one of the established remedies for tuberculosis. The objective of the current study was to investigate in vitro antimycobacterial activity as well as anti-bacterial activity of various extracts rich in specific phytoconstituents from garlic. Preparation of garlic extracts was done based on the chemistry of the constituents and their stability. The estimation of in vitro antimycobacterial activity of different garlic extracts was done using Resazurin microtire plate assay technique whereas activity of garlic oil was evaluated by colony count method. The antibacterial activity of extracts and oil was estimated by zone of inhibition method. Extracts of garlic rich in allicin and ajoene showed appreciable antimycobacterial activity as compared to standard drugs. Garlic oil demonstrated significant antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus.

Keywords: Ajoene; allicin; antimycobacterial; garlic oil; resazurin microtitre assay

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