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Cunico C, Picheth G, Correr CJ, et al. Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study. Pharm Pract (Granada). 2014;12(2):378doi: 10.4321/s1886-36552014000200002.
Cunico, C., Picheth, G., Correr, C. J., & Scartezini, M. (2014). Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study. Pharmacy practice, 12(2), 378. https://doi.org/10.4321/s1886-36552014000200002
Cunico, Cássia, et al. "Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study." Pharmacy practice vol. 12,2 (2014): 378. doi: https://doi.org/10.4321/s1886-36552014000200002
Cunico C, Picheth G, Correr CJ, Scartezini M. Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study. Pharm Pract (Granada). 2014 Apr;12(2):378. doi: 10.4321/s1886-36552014000200002. Epub 2014 Mar 15. PMID: 25035713; PMCID: PMC4100947.
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Pharm Pract (Granada). 2014 Apr;12(2):378. doi: 10.4321/s1886-36552014000200002. Epub 2014 Mar 15.

Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study.

Pharmacy practice

Cássia Cunico, Geraldo Picheth, Cassyano J Correr, Marileia Scartezini

Affiliations

  1. Municipal Health of the São Miguel do Oeste and State Health Administration of the State of Santa Catarina. Florianópolis ( Brazil ).
  2. Department of Medical Pathology, Federal University of Parana (UFPR) , Curitiba, PR ( Brazil ).
  3. Department of Pharmacy, Federal University of Parana (UFPR) Curitiba, PR ( Brazil ).

PMID: 25035713 PMCID: PMC4100947 DOI: 10.4321/s1886-36552014000200002

Abstract

OBJECTIVE: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice.

METHODS: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population studied consists of patients assisted by the Public Health Service in the far-west region of the State of Santa Catarina, Brazil. The Medication Possession Ratio obtained from pharmacy refill data was used to measure patient adherence. Therapeutic effectiveness was evaluated based on the difference obtained in the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, before and after taking the drug, in an average time of 8.3 months.

RESULTS: Following the treatment with hypolipidemic agents, it has been observed a reduction of 14.3% for total cholesterol, 19.6% for LDL-cholesterol, and 14.4% for triglycerides. HDL-cholesterol increased by an 8.0% average. The major changes in lipid profile were promoted by atorvastatin 20 mg daily. The medication adherence rate decreased over the monitoring period. Adherence rates below 60% were associated with therapeutic failure, while rates equal to 80% or higher were associated with the best response to the lipid-lowering drugs.

CONCLUSION: Adherence to hypolipidemic agents is higher at the beginning of the treatment, but it decreases over time, affecting the achievement of therapeutic goals.

Keywords: Brazil; Hypolipidemic Agents; Medication Adherence; Outcome and Process Assessment (Health Care); Primary Health Care

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