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Cerny J, Devitt K, Yu H, et al. Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation. Leuk Res Rep. 2014;3(2):51-3doi: 10.1016/j.lrr.2014.06.002.
Cerny, J., Devitt, K., Yu, H., Ramanathan, M., Woda, B., & Nath, R. (2014). Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation. Leukemia research reports, 3(2), 51-3. https://doi.org/10.1016/j.lrr.2014.06.002
Cerny, Jan, et al. "Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation." Leukemia research reports vol. 3,2 (2014): 51-3. doi: https://doi.org/10.1016/j.lrr.2014.06.002
Cerny J, Devitt K, Yu H, Ramanathan M, Woda B, Nath R. Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation. Leuk Res Rep. 2014 Jul 04;3(2):51-3. doi: 10.1016/j.lrr.2014.06.002. eCollection 2014. PMID: 25068102; PMCID: PMC4110356.
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Leuk Res Rep. 2014 Jul 04;3(2):51-3. doi: 10.1016/j.lrr.2014.06.002. eCollection 2014.

Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation.

Leukemia research reports

Jan Cerny, Katherine Devitt, Hongbo Yu, Muthalagu Ramanathan, Bruce Woda, Rajneesh Nath

Affiliations

  1. Division of Hematology Oncology, Department of Medicine, UMass Memorial Medical Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
  2. Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

PMID: 25068102 PMCID: PMC4110356 DOI: 10.1016/j.lrr.2014.06.002

Abstract

The optimal salvage therapy for patients with relapsed Burkitt lymphoma is unknown. Bone marrow necrosis is an underreported (<1% of bone marrow failures). Numb chin syndrome is another rare syndrome associated with aggressive malignancies. Survival of these syndromes is dictated by the underlying disease and is usually dismal. Our 35-year-old patient experienced an early relapse of Burkitt lymphoma accompanied by syndromes, achieved second complete remission and underwent allogeneic stem cell transplantation. He remains alive and well >2 years after the transplant. To our knowledge, this is the longest reported survival of the two syndromes in the setting of BL relapse.

Keywords: Allogeneic; Bone marrow necrosis; Burkitt lymphoma; Numb chin syndrome; Salvage

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