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Heidarifar R, Mehran N, Heidari A, et al. Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial. J Res Med Sci. 2014;19(4):326-30
Heidarifar, R., Mehran, N., Heidari, A., Tehran, H. A., Koohbor, M., & Mansourabad, M. K. (2014). Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(4), 326-30.
Heidarifar, Reza, et al. "Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial." Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 19,4 (2014): 326-30.
Heidarifar R, Mehran N, Heidari A, Tehran HA, Koohbor M, Mansourabad MK. Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial. J Res Med Sci. 2014 Apr;19(4):326-30. PMID: 25097605; PMCID: PMC4115348.
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J Res Med Sci. 2014 Apr;19(4):326-30.

Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Reza Heidarifar, Nahid Mehran, Akram Heidari, Hoda Ahmari Tehran, Mohammad Koohbor, Mostafa Kazemian Mansourabad

Affiliations

  1. Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
  2. Traditional Medicine Research Center, Qom University of Medical Sciences, Qom, Iran.
  3. Research Center for Medicine and Religion, Qom University of Medical Sciences, Qom, Iran.
  4. Department of Basic Sciences, Qom University, Qom, Iran.

PMID: 25097605 PMCID: PMC4115348

Abstract

BACKGROUND: Dysmenorrhea has negative effects on women's life. Due to side-effects of chemical drugs, there is growing trend toward herbal medicine. The aim of this study was to assess the effect of Dill compared to mefenamic acid on primary dysmenorrhea.

MATERIALS AND METHODS: This double-blind, randomized, clinical trial study was conducted on 75 single female students between 18 and 28 years old educating in Nursing and Midwifery School and Paramedical Faculty of Qom University of Medical Sciences of Iran in 2011. They were allocated randomly into one of the three groups: In Dill group, they took 1000 mg of Dill powder q12h for 5 days from 2 days before the beginning of menstruation for two cycles. Other groups received 250 mg mefenamic acid or 500 mg starch capsule as placebo, respectively. Dysmenorrhea severity was determined by a verbal multidimensional scoring system and a visual analog scale (VAS). Students with mild dysmenorrhea were excluded. Data were analyzed by SPSS using the descriptive statistic, paired-samples t-test, Wilcoxon signed-rank test, Mann-Whitney test, and Kruskal-Wallis test.

RESULTS: There were no significant differences between three groups for demographic or descriptive variables. Comprising the VAS showed that the participants of Dill and mefenamic acid groups had lower significant pain in the 1(st) and the 2(nd) months after treatment, whereas in the placebo group this was only significant in the 2(nd) month (P < 0.05).

CONCLUSION: Dill was as effective as mefenamic acid in reducing the pain severity in primary dysmenorrhea. Further studies regarding side-effects of Dill and its interactivity are recommended.

Keywords: Dill (Anethum graveolens); dysmenorrhea; mefenamic acid; pain; placebo

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